Native Rat Hemopexin

• Cat.No.: HPX-84R

Specification

• Description: Hemopexin is a single-chain protein belonging to the family of blood transport proteins. It binds to heme released into the bloodstream during the degradation process. Recent studies have demonstrated that hemopexin acts as an extracellular antioxidant against hemoglobin-mediated damage in inflammation. Hemopexin protects against heme toxicity and conserves and recycles iron. Abnormal levels of hemopexin are associated with hemolytic anemia, chronic neuromuscular disease, and acute intermittent porphyria.
• Source: Rat Serum
• Species: Rat
• Form: Lyophilized
• Molecular Mass: 57.0 kDa
• Purity: Purity by SDS-PAGE: ≥95%
• Usage: For Research Use Only! Not For Use in Humans.
• Notes: Centrifuge the vial prior to opening
• Storage: -20°C
• Storage Buffer: Lyophilized from 11.9 mM phosphate, 137 mM NaCl, 2.7 mM KCl, pH 7.4.
• Shipping: Gel pack

Gene Information

• Gene Name: Hpx hemopexin [ Rattus norvegicus ]
• Official Symbol: HPX
• Synonyms: HPX; hemopexin; Hpxn
• Gene ID: 58917
• mRNA Refseq: NM_053318
• Protein Refseq: NP_445770
• Function: metal ion binding

Reviews

12/09/2019

the manufacturer offers a wide range of HPX protein variants, including recombinant or native forms, as well as different conjugates and modifications.

02/02/2018

As a researcher using HPX protein, I have found numerous advantages in its application during trials for various experimental purposes.

08/15/2017

the HPX protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.

Q&As

Can HPX be used as a diagnostic marker for hemolytic disorders?

Yes, low levels of HPX in the blood can be an indicator of hemolytic disorders.

How is HPX involved in managing heme in the body?

HPX binds to free heme released from hemoglobin, preventing its toxic effects and aiding in its clearance.

How does HPX contribute to the prevention of heme-related toxicity?

HPX binds to heme, preventing its oxidative and inflammatory damage to tissues and organs.

What clinical conditions are associated with heme release, making HPX relevant?

Hemolysis, hemoglobinopathies, and various types of anemias can lead to heme release, highlighting the clinical relevance of HPX.

How is HPX regulated in the body, and can its levels be influenced by medications?

HPX levels can be influenced by various factors, including inflammation and medications like glucocorticoids.