Recombinant Active Human MYT1 Protein (Full length), N-His-tagged

• Cat.No.: MYT1-17H
• Product Overview: Recombinant full-length human MYT1 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Description: MYT1 is a member of a family of neural specific, zinc finger-containing DNA-binding proteins which binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. The recombinant MYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn (2+), but not other divalent cations.
• Source: Sf9 insect cells
• Species: Human
• Tag: N-His
• Bio-activity: The specific activity of MYT1 was determined to be 14 nmol/min/mg as per actity assay protocol.
• Molecular Mass: Observed MW: ~65 kDa.
  Calculated MW: ~58.7 kDa.
• Protein Length: Full length
• Purity: The purity of MYT1 was determined to be > 90 % by densitometry.
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol.
• Shipping: Dry ice

Gene Information

• Gene Name: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 [ Homo sapiens (human) ]
• Official Symbol: MYT1
• Synonyms: PKMYT1; protein kinase, membrane associated tyrosine/threonine 1; MYT1; PPP1R126; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; myt1 kinase; protein phosphatase 1, regulatory subunit 126; EC 2.7.11.1
• Gene ID: 9088
• mRNA Refseq: NM_004203
• Protein Refseq: NP_004194
• MIM: 602474
• UniProt ID: Q99640

Reviews

06/02/2021

MYT1 is highly expressed, which can effectively synthesize a large number of target proteins in host cells.

10/05/2020

MYT1 is highly pure and not adulterated with other proteins or impurities.

06/24/2020

Laboratory personnel reported that the protein was easy to handle, able to meet the needs of experiments, and had a good price-performance ratio.

Q&As

What is the association between MYT1 recombinant protein and tumors?

Studies have shown that MYT1 recombinant protein may be involved in the occurrence and progression of tumors, especially in neurological tumors and breast cancer.

What are the treatments for MYT1 recombinant protein?

The current treatments for MYT1 recombinant protein mainly include gene therapy, protein replacement therapy, and drug therapy for cell cycle and DNA repair processes.

How to detect the level of MYT1 recombinant protein?

The level of MYT1 recombinant protein can be detected by gene sequencing and protein detection methods.

What diseases is MYT1 recombinant protein associated with?

MYT1 recombinant protein is associated with some tumors, neurological diseases, and autoimmune diseases.

If the level of MYT1 recombinant protein is abnormal, what should I do?

If the level of MYT1 recombinant protein is abnormal, the treatment may include the use of drugs or other special treatments, depending on the condition and the doctor's recommendation.

How about the association between MYT1 recombinant protein and other systemic diseases?

Studies have shown that MYT1 recombinant protein may be associated with cardiovascular disease, liver disease, and lung disease.