Recombinant Bovine PPT1 protein(28-306aa), His&Myc-tagged

• Cat.No.: PPT1-7432B
• Product Overview: Recombinant Bovine PPT1 protein(P45478)(28-306aa), fused with N-terminal His tag and C-terminal Myc tag, was expressed in E.coli.

Specification

• Source: E.coli
• Species: Bovine
• Tag: N-His&C-Myc
• Protein length: 28-306aa
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 38.9 kDa
• AASequence: DPPAPLPLVIWHGMGDSCCNPLSMG AIKKMVEKKIPGIHVLSLEIGKTLR EDVENSFFLNVNSQVTTVCQILAKD PKLQQGYNAMGFSQGGQFLRAVAQR CPSPPMVNLISVGGQHQGVFGLPRC PGESSHICDFIRKTLNAGAYNKAIQ ERLVQAEYWHDPIREDIYRNHSIFL ADINQERGVNESYKKNLMALKKFVM VKFLNDTIVDPVDSEWFGFYRSGQA KETIPLQESTLYTQDRLGLKAMDKA GQLVFLALEGDHLQLSEEWFYAHII PFLE
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C.

Reviews

11/20/2022

It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

04/21/2020

Incorporating the PPT1 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

09/01/2017

Researchers can leverage the unique properties of the PPT1 protein to gain insights into its biological functions and its impact on disease mechanisms.

Q&As

Can PPT1 mutations lead to other health problems beyond NCL?

PPT1 mutations are primarily associated with NCL, but they can have varying effects on patients, and in some cases, they may present with atypical symptoms.

What medical condition is associated with mutations in the PPT1 gene?

Mutations in the PPT1 gene are linked to Neuronal Ceroid Lipofuscinosis (NCL), a group of rare neurodegenerative disorders.

What are the clinical symptoms of NCL caused by PPT1 deficiency?

Patients with PPT1-related NCL typically experience vision loss, seizures, cognitive decline, and motor dysfunction.

Is there a cure for NCL caused by PPT1 mutations?

Currently, there is no cure for NCL. Treatment focuses on managing symptoms and improving the quality of life.

How does PPT1 deficiency lead to NCL?

PPT1 deficiency results in the accumulation of lipofuscin, a fatty substance, in neurons, which causes neurodegeneration.