Recombinant Bovine PRNP Protein

• Cat.No.: PRNP-290B
• Product Overview: Recombinant Bovine PRNP(24-241 aa) was expressed in E. coli.

Specification

• Description: Prion Protein (PrP) is an abundant cellular protein in mammalian neural tissue. It is associated with mammalian prion diseases, e.g. transmissible spongiforme encephalophathies that include human Creutzfeld-Jakob disease, bovine spongiforme encephalopathy, sheep scrapie, cervid’s chronic wasting disease and various rodent prion diseases. In the disease process, PrP undergoes protein aggregation into disease specific PrPSc.
• Source: E. coli
• Species: Bovine
• Form: Finally dialysed in pure water, shock frozen in liquid nitrogen at a protein concentration of 0.25 mg/ml.
• Molecular Mass: 23163 kg/mol
• Protein length: 24-241 aa
• AA Sequence: GSKKRPKPGGGWNTGGSRYPGQGSP GGNRYPPQGGGGWGQPHGGGWGQPH GGGWGQPHGGGWGQPHGGGWGQPHG GGGWGQGGTHGQWNKPSKPKTNMKH VAGAAAAGAVVGGLGGYMLGSAMSR P
  LIHFGSDYEDRYYRENMHRYPNQVY YRPVDQYSNQNNFVHDCVNITVKEH TVTTTTKGENFTETDIKMMERVVEQ MCITQYQRESQAYYQRGA
• Purity: > 95% by SDS-PAGE
• Applications: Prion Protein is frequently used in analytical aggregation assays
• Notes: Thawing: Gentle agitation at 37 centigrade until no ice is left. Keep on ice. Do not refreeze
• Storage: Store at -80 centigrade
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: PRNP prion protein [ Bos taurus ]
• Official Symbol: PRNP
• Synonyms: PrP; AltPrP; prion protein precursor PrP; prion protein variant a; prion protein variant b
• Gene ID: 281427
• mRNA Refseq: NM_001271625
• Protein Refseq: NP_001258554
• UniProt ID: F7VJQ2