Recombinant Chicken ACTC1
Cat.No. : | ACTC1-3520C |
Product Overview : | Recombinant Chicken ACTC1 full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Chicken |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | ACTC1 actin, alpha, cardiac muscle 1 [ Gallus gallus (chicken) ] |
Official Symbol : | ACTC1 |
Gene ID : | 423298 |
Protein Refseq : | NP_001072949 |
UniProt ID : | P68034 |
Products Types
◆ Recombinant Protein | ||
ACTC1-283M | Recombinant Mouse ACTC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTC1-135R | Recombinant Rat ACTC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACTC1-268H | Recombinant Human ACTC1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Actc1-813M | Recombinant Mouse Actc1 Protein, MYC/DDK-tagged | +Inquiry |
ACTC1-1241M | Recombinant Mouse ACTC1 Protein | +Inquiry |
◆ Native Protein | ||
ACTC1-852B | Native Bovine ACTC1 Protein | +Inquiry |
ACTC1-885B | Native Bovine ACTC1 Protein, Pyrene labeled | +Inquiry |
ACTC1-166B | Active Native bovine ACTC1 | +Inquiry |
◆ Lysates | ||
ACTC1-9065HCL | Recombinant Human ACTC1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionACTC1 mutations, such as the G247D mutation, have been linked to atrial-septal defect followed by late-onset dilated cardiomyopathy (DCM).
Knockdown of ACTC1 inhibits U87MG cell migration.
Significant expression quantitative trait loci (eQTL) associated with Actc1 expression have been identified in both heart and soleus (a skeletal muscle)
ACTC1 mutations have been implicated in atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
ACTC1 encodes a highly conserved actin protein that binds to myosin in both cardiac and skeletal muscle, suggesting shared functions between the two muscle types.
Mutations in the ACTA1 gene, which encodes skeletal muscle α-actin, can cause lethal muscle diseases. However, transgenic over-expression of cardiac α-actin (ACTC1) has been shown to rescue the disease phenotype in ACTA1 mouse models.
The discovery of mutations in ACTC1 expands our knowledge of genetic disorders and identifies a new condition associated with ACTC1 mutations, highlighting the importance of this gene in muscle-related conditions.
Mutations in ACTC1 have been linked to atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.
The G247D ACTC1 mutation negatively regulates serum response (SRF)-signaling, which contributes to the development of late-onset DCM.
Transgenic over-expression of ACTC1 rescues the disease phenotype observed in ACTA1 mouse models, which are affected by lethal muscle diseases.
Studies have examined methylation, histone modification, and chromatin accessibility as marks of regulatory potential, with methylation around the Actc1 transcriptional start site showing a strain-dependent correlation with Actc1 expression in skeletal muscle.
The shared functions of ACTC1 in both cardiac and skeletal muscle indicate overlapping roles and potential implications for muscle function and disease processes.
Actc1 expression can vary up to 24-fold in skeletal muscle among different strains, as observed in the strains from The Collaborative Cross (CC) genetic resource.
ACTC1 has been identified as a potential marker to detect GBM migration in clinical cases.
The highly conserved nature of the ACTC1 actin protein suggests its fundamental importance in muscle function across species.
The shared functions of ACTC1 in cardiac and skeletal muscle indicate potential overlapping mechanisms in muscle-related diseases and may guide future research and therapeutic approaches targeting ACTC1-related conditions.
ACTC1 is the predominant striated α-actin isoform in the heart.
Methylation around the Actc1 transcriptional start site in early adult skeletal muscle negatively correlates with Actc1 expression in a strain-dependent manner, indicating a potential regulatory role.
Reduced ACTC1 expression may contribute to the onset of congenital heart disease (CHD) through the induction of cardiomyocyte apoptosis.
Actc1 expression can vary up to 24-fold in skeletal muscle, as observed in strains from The Collaborative Cross (CC) genetic resource.
Customer Reviews (5)
Write a reviewThe protein product delivers exceptional results, surpassing our expectations in terms of its effectiveness.
The protein product demonstrates exceptional purity, free from any interfering impurities.
The protein product maintains remarkable consistency across multiple batches, ensuring reproducibility in our experiments.
The customer support provided by the company is exceptional, promptly addressing any inquiries or concerns.
The protein product was delivered in a timely manner, and the packaging was secure, ensuring product integrity.
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