Recombinant Cynomolgus AMHR2 protein, His-tagged

• Cat.No.: AMHR2-0489C
• Product Overview: Recombinant Cynomolgus AMHR2 protein(Pro18-Ser144), fused with His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Cynomolgus
• Tag: His
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally trehalose is added as protectant before lyophilization.
• Molecular Mass: This protein carries a polyhistidine tag at the C-terminus.The protein has a calculated MW of 15.4 kDa. The protein migrates as 20-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Proteinlength: Pro18-Ser144
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Reviews

07/31/2022

Reliable detection of protein-protein interaction dynamics.

11/23/2020

Accurate determination of protein complex composition.

11/10/2017

Compatibility with challenging sample types (e.g., crude extracts).

Q&As

How does AMHR2 contribute to the development and maintenance of male and female reproductive organs?

AMHR2 is involved in the development and maintenance of male and female reproductive organs, including the testes, ovaries, and genital ducts.

What are the functional consequences of AMHR2 mutations or dysregulation on reproductive health and fertility?

Mutations or dysregulation of AMHR2 can lead to reproductive abnormalities, such as persistent M眉llerian duct syndrome or disorders of sexual development.

What is the role of AMHR2 in mediating AMH-induced M眉llerian duct regression during male sexual differentiation?

AMHR2 plays a crucial role in mediating the AMH-induced regression of M眉llerian ducts in male embryos, allowing for the development of the male reproductive system.

What is the role of AMHR2 in non-reproductive tissues or diseases outside the reproductive system?

Besides its role in the reproductive system, AMHR2 may have additional functions in non-reproductive tissues or diseases, highlighting its potential as a therapeutic target beyond reproduction.

How does AMHR2 signaling cross-talk with other signaling pathways involved in reproductive processes, such as the Wnt/尾-catenin or Notch pathways?

AMHR2 signaling pathways may cross-talk with other signaling pathways, such as the Wnt/尾-catenin or Notch pathways, to fine-tune reproductive processes and organ development.

What are the genetic and epigenetic factors that influence AMHR2 expression and its variations among individuals?

AMHR2 expression can be influenced by genetic variations and epigenetic modifications that contribute to inter-individual differences in AMHR2 levels.

How does AMHR2 interact with AMH ligand and other co-receptors to initiate signaling cascades?

AMHR2 forms a complex with AMH ligand and the co-receptor, AMH receptor type 2 (ACVR2A), to initiate signaling cascades.

How is AMHR2 expression regulated during embryonic development and tissue-specific differentiation?

AMHR2 expression is regulated by various factors during embryonic development and tissue-specific differentiation, including transcription factors and hormonal cues.

Can modulating AMHR2 signaling pathways be a potential therapeutic approach for reproductive disorders or conditions with abnormal M眉llerian duct development?

Modulating AMHR2 signaling pathways may hold therapeutic potential for managing reproductive disorders characterized by abnormal M眉llerian duct development or function.

What are the downstream signaling pathways activated by AMHR2 and their roles in reproductive organ development and homeostasis?

AMHR2 activates the Smad signaling pathway, leading to downstream gene expression changes involved in reproductive organ development and maintenance.