Recombinant Cynomolgus CD4, His tagged
Cat.No. : | CD4-01H |
Product Overview : | Recombinant Cynomolgus CD4 with C-terminal His6 fusion tag was expressed in HEK293. |
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Description : | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages |
Source : | HEK293 |
Species : | Macaca Fascicularis |
Tag : | His |
Form : | Lyophilized powder |
Molecular Mass : | 41.5 kDa |
Protein length : | 373 |
AA Sequence : | KKVVLGKKGDTVELTCNASQKKNTQ FHWKNSNQIKILGIQGSFLTKGPSK LSDRADSRKSLWDQGCFSMIIKNLK IEDSDTYICEVENKKEEVELLVFGL TANSDTHLLEGQSLTLTLESPPGSS PSVKCRSPGGKNIQGGRTLSVPQLE RQDSGTWTCTVSQDQKTVEFKIDIV VLAFQKASSTVYKKEGEQVEFSFPP AFTLEKLTGSGELWWQAERASSSKS WITFDLKNKEVSVKRVTQDPKLQMG KKLPLHLTLPQALPQYAGSGNLTLA LEAKTGKLHQEVNLVVMRATQFQEN LTCEVWGPTSPKLTLSLKLENKGTT VSKQAKAVWVLNPEAGMWQCLLSDS GQVLLESNIKVVPTWHHHHHHHH |
Endotoxin : | <1EU/ug by LAL |
Purity : | >95% by SDS-PAGE |
Applications : | ELISA |
Storage : | Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. 5% trehalose and mannitol are added as protectants before lyophilization. |
Gene Name : | CD4 |
Official Symbol : | CD4 |
Synonyms : | CD4mut,LEU3 |
Gene ID : | 101864991 |
mRNA Refseq : | MF632290.1 |
Protein Refseq : | P79185.1 |
UniProt ID : | P79185 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (3)
Ask a questionCD4 binds to glycoprotein GP120.
CD4 is mainly expressed in T cells and thymocytes.
CD4 is localized in the cell membrane.
Customer Reviews (3)
Write a reviewThe CD4 proteins purchased from your company is suitable for ELISA.
Protein products are put into experiments with good effect and reliable experimental results.
The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.
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