Recombinant Cynomolgus DNASE1, Fc tagged

• Cat.No.: IL6ST-144C
• Product Overview: Recombinant Cynomolgus DNASE1 (NP_005214.2) (Met1-Ile618), fused with the Fc region of human IgG1 at the C-terminus, was produced in Human Cells.

Specification

• Source: Human Cells
• Species: Cynomolgus
• Tag: Fc
• Predicted N Terminal: Glu 23
• Form: Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
• Molecular Mass: The recombinant cynomolgus IL6ST is a disulfide-linked homodimer. The reduced monomer comprises 837 amino acids and has a calculated molecular mass of 94.8 KDa.The apparent molecular mass of the protein is approximately 116 KDa respectively in SDS-PAGE.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >85 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70oC.
• Storage: Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: DNASE1?deoxyribonuclease I [?Macaca fascicularis?(crab-eating macaque) ]
• Official Symbol: DNASE1
• Gene ID: 102133646
• mRNA Refseq: XM_005591097
• Protein Refseq: XP_005591154
• Chromosome Location: 20

Reviews

12/06/2022

Dependable antibody validation, vital for our immunoprecipitation studies.

01/10/2022

Top-quality protein purification service, essential for our lab's work.

02/22/2019

Fast and reliable protein expression, a critical part of our projects.

Q&As

How does DNASE1 (Deoxyribonuclease I) contribute to DNA degradation and clearance, particularly in apoptotic cells?

DNASE1 helps degrade DNA in apoptotic cells, ensuring proper clearance and preventing inflammation.

How does DNASE1 deficiency lead to the development of systemic lupus erythematosus (SLE) and other autoimmune diseases?

DNASE1 deficiency can contribute to autoimmune diseases like SLE by allowing self-DNA accumulation.

What is the impact of DNASE1 on the regulation of inflammation and immune system activation?

DNASE1 regulates inflammation and immune responses by controlling extracellular DNA levels.

How does DNASE1 influence the resolution of inflammation and tissue repair processes?

DNASE1 aids in resolving inflammation and promoting tissue repair by degrading DNA in damaged tissues.

What are the mechanisms by which DNASE1 modulates the stability and integrity of extracellular DNA?

DNASE1 maintains the stability and integrity of extracellular DNA, preventing inappropriate immune activation.

How do alterations in DNASE1 expression or activity affect susceptibility to chronic inflammatory conditions?

Changes in DNASE1 function can increase susceptibility to chronic inflammation and autoimmune disorders.

What role does DNASE1 play in preventing the accumulation of self-DNA and autoimmune responses?

DNASE1 prevents the accumulation of self-DNA, reducing the risk of autoimmune reactions.