Recombinant Cynomolgus Monkey ABHD12 Protein Pre-coupled Magnetic Beads

• Cat.No.: ABHD12-12C-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Cynomolgus Monkey
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ABHD12 Monoacylglycerol lipase ABHD12 [ Macaca fascicularis (crab-eating macaque) ]
• Official Symbol: ABHD12
• Synonyms: ABHD12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12
• Gene ID: 101867434
• mRNA Refseq: NM_001284729
• Protein Refseq: NP_001271658
• UniProt ID: Q4R766

Reviews

06/10/2020

The product description covers all product attributes and application methods, and will repurchase.

02/27/2020

The packaging is intact with clear labels, cool.

09/12/2019

Reasonable price!

Q&As

Where (which organs) does the ABHD12 overexpress?

This gene is overexpressed in nasal epithelium and bone.

What is the mechanism action of the ABHD12 in the drug called Orlistat?

Lipase inhibitor for obesity treatment, Small Molecule, Anti-Obesity Agents, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity

List at least three biological process for ABHD12 gene?

Phospholipid catabolic process, Lipid metabolic process, and Protein depalmitoylation.

What are the top five Interacting proteins for ABHD12 gene?

They are DPP9, HSCB, COASY, SLC39A4, and SRSF1.

List at least three reactome pathways for ABHD12 gene?

Arachidonate production from DAG, Effects of PIP2 hydrolysis, and GPCR downstream signalling.

How to determine the corelation between breast cancer and the ABHD12 expression?

It can be determined by analysing ABHD12 mRNA expression in breast cancer tissues and healthy tissues, based on a series of research, we found that mRNA expression profile revealed that the ABHD12 transcript is highly expressed in tissues of patients with breast cancer compared to that expressed in healthy tissues adjacent to tumour.

What will happen if the ABHD12 was disrupted in mice ?

Disruption of ABHD12 in mice leads to (i) accumulation of lyso-PS in the cerebellum breaching the homeostatic threshold, inducing continuous stimulation of the Purkinje neurons, leading to deregulated cerebellar activity and (ii) increased levels of microglial activation and inflammation. Accompanying this inflammatory response in mice are behavioral deficits, including sensorimotor defects and hearing loss.

Brefily introduce a molecular function of ABHD12?

Lysophosphatidylserine (i.e. ABHD12) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes, represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system.

What disease will occur if the ABHD12 mutate?

Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract)

Why ABHD12 mutation can results of a series of neurodegenerative diseases?

It is because this gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation