| Description : |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. |
| Source : |
HEK293 |
| Species : |
Cynomolgus monkey |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
46.3 kDa |
| Protein Length : |
421 |
| AA Sequence : |
ESAAPVPQALLLVLLGARAQGGTQS PRCDCAGDFHKKNGVFCCRGCPAGH YLKAPCTEPCGNSTCLLCPQDTFLA WENHHNSECARCQACDEQASQVALE NCSAVADTRCGCKPGWFVECQVSQC VSSSPFYCQPCLDCRALHRHTRLLC SRRDTDCGTCLPGFYEHDDGCVSCP TPPPSLSGAPWGAVQSAVPLSVAGG RVGVFWVQVLLAGLVVPLLLGATLT YTYRHCWPHKPMVTADEAGMEALTP PPATHLSPSDKAHTLLVPPDSSEKI CTVQLVDNSWTPGYPHTQEALCPQM TWSWDQLPNRALGPVPASTLLPESP VGSPTMMLQPGPQLYDVMDAVPARR WKEFVRTLGLREAEIEAVEVEIGRF RDQQYEMLKRWRQQQPAGLGAVYAA LERMGLDGCAEDLRSRLQRGP |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
