Recombinant Full Length Human ABCC5 Protein, GST-tagged
Cat.No. : | ABCC5-770HF |
Product Overview : | Human ABCC5 full-length ORF ( NP_001018881.1, 1 a.a. - 208 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 50.1 kDa |
Protein Length : | 208 amino acids |
AA Sequence : | MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI LSIVCLMITQ LAGFSGPNFQ DGCILRSE |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 [ Homo sapiens ] |
Official Symbol : | ABCC5 |
Synonyms : | ABCC5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; multidrug resistance-associated protein 5; EST277145; MOAT C; MRP5; SMRP; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; canalicular multispecific organic anion transporter C; ABC33; MOATC; MOAT-C; pABC11; DKFZp686C1782 |
Gene ID : | 10057 |
mRNA Refseq : | NM_001023587 |
Protein Refseq : | NP_001018881 |
MIM : | 605251 |
UniProt ID : | O15440 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionProgesterone, testosterone and their analogues
No clear research results. But the down-regulation of ABCC5 expression could significantly reduce the resistance of sorafenib to HCC cells.
The expression levels of ABCC2, ABCC4, ABCC5, and ABCG2 significantly increased in the pan-resistant cell line, and the ABCC5 level in the MCF-7-ADR cell line was 5.21 times higher than that in the control group.
MRP4 (ABCC4) and MRP5 (ABCC5) are organic anion transporters.
PLEKHA7, ABCC5, and KALRN have been identified as susceptible genetic markers related to glaucoma.
There is no clear result now. Some research show that ABCC5 was differently expressed and strongly related to the pathological stage of LIHC.
Not in all the tumors. Small molecular inhibitors of FOXM1 or ABCC5 have the potential to overcome paclitaxel chemoresistance in nasopharyngeal carcinoma patients
The role of ABCC5 in diabetes and obesity is unknown. ABCC5 protein expression levels are inversely related to fat mass and appear to play a role in the regulation of GLP-1 secretion from enteroendocrine cells.
No result shows that ABCC5 mutation will lead to diabetes. Research shows that ABCC5 transporter is a new type 2 diabetes susceptibility gene
Some study demonstrated that ABCC5 knockdown significantly inhibits PCa cell proliferation, migration, and invasion in vitro and suppresses tumor growth and metastasis in vivo.
It has not yet been reported.
There are many polymorphisms on ABCC5, such as, ABCC5 g.+7161G>A (rs1533682),g.+7161AA,g.+7161GG,g.-1679T>A, c.2T>C, c.343A>G, and c.1573G>A.
More research data are needed to prove.A study shows that the expression of ABCC5 was up-regulated in HCC and was associated with poor prognosis.
The protein is widely expressed in various tissues, with particularly high levels observed in the liver, kidney, and prostate.
Yes, please contact us for more information.
In adults, zebrafish abcc5 is extensively expressed, at higher levels in testis, brain, eye, ovary, intestine and kidney, but at relatively lower levels in gill, liver, heart and muscle.
Customer Reviews (3)
Write a reviewReasonable price and high quality
It is cost-effective to buy when promoting
There are many expression systems to choose from
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