Recombinant Full Length Human ACADL Protein, GST-tagged

• Cat.No.: ACADL-895HF
• Product Overview: Human ACADL full-length ORF ( AAH39063, 1 a.a. - 430 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 73.04 kDa
• Protein Length: 430 amino acids
• AA Sequence: MAARLLRGSL RVLGGHRAPR QLPAARCSHS GGEERLETPS AKKLTDIGIR RIFSPEHDIF RKSVRKFFQE EVIPHHSEWE KAGEVSREVW EKAGKQGLLG VNIAEHLGGI GGDLYSAAIV WEEQAYSNCS GPGFSIHSGI VMSYITNHGS EEQIKHFIPQ MTAGKCIGAI AMTEPGAGSD LQGIKTNAKK DGSDWILNGS KVFISNGSLS DVVIVVAVTN HEAPSPAHGI SLFLVENGMK GFIKGRKLHK MGLKAQDTAE LFFEDIRLPA SALLGEENKG FYYIMKELPQ ERLLIADVAI SASEFMFEET RNYVKQRKAF GKTVAHLQTV QHKLAELKTH ICVTRAFVDN CLQLHEAKRL DSATACMAKY WASELQNSVA YDCVQLHGGW GYMWEYPIAK AYVDARVQPI YGGTNEIMKE LIAREIVFDK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACADL acyl-CoA dehydrogenase, long chain [ Homo sapiens ]
• Official Symbol: ACADL
• Synonyms: ACADL; acyl-CoA dehydrogenase, long chain; acyl Coenzyme A dehydrogenase, long chain; long-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD4; LCAD; acyl-Coenzyme A dehydrogenase, long chain; FLJ94052
• Gene ID: 33
• mRNA Refseq: NM_001608
• Protein Refseq: NP_001599
• MIM: 609576
• UniProt ID: P28330

Reviews

04/04/2019

Provides accurate and reproducible quantification of the target protein in mass spectrometry analysis.

09/10/2017

Shows excellent performance in detecting and quantifying the expression levels of recombinant proteins in protein expression analysis.

Q&As

How does the activity of this protein contribute to cellular metabolism?

The activity of acyl-CoA dehydrogenase long chain contributes to the breakdown of long-chain fatty acids to produce energy in cells.

How is the expression of acyl-CoA dehydrogenase long chain regulated?

The expression of acyl-CoA dehydrogenase long chain is regulated by a variety of factors, including gene expression and protein degradation pathways.

Where is acyl-CoA dehydrogenase long chain protein located within the cell?

Acyl-CoA dehydrogenase long chain protein is located in the mitochondrial matrix.

Are there any known inhibitors or activators of this protein?

There are currently no known inhibitors or activators of acyl-CoA dehydrogenase long chain protein.

What is the substrate specificity of this protein?

Acyl-CoA dehydrogenase long chain protein has specificity for long-chain fatty acyl-CoA substrates.

What research is currently being conducted to further understand the function of acyl-CoA dehydrogenase long chain protein?

Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase long chain protein, as well as its role in metabolic disorders.

What are the physiological roles of acyl-CoA dehydrogenase long chain?

Acyl-CoA dehydrogenase long chain plays a key role in energy metabolism and fatty acid oxidation in cells.

What is the function of acyl-CoA dehydrogenase long chain protein?

Acyl-CoA dehydrogenase long chain protein catalyzes the first step in the 尾-oxidation of long-chain fatty acids.

What diseases or disorders are associated with mutations in this protein?

Mutations in this protein are associated with a variety of metabolic disorders, including long-chain acyl-CoA dehydrogenase deficiency.

What is the structure of this protein and how does it relate to its function?

Acyl-CoA dehydrogenase long chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.