Recombinant Full Length Human ACSF2 Protein, GST-tagged

• Cat.No.: ACSF2-787HF
• Product Overview: Human ACSF2 full-length ORF ( NP_079425.2, 1 a.a. - 615 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ACSF2 (Acyl-CoA Synthetase Family Member 2) is a Protein Coding gene. Among its related pathways are Metabolism and Mitochondrial LC-Fatty Acid Beta-Oxidation. GO annotations related to this gene include ligase activity. An important paralog of this gene is ACSF3.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 94.6 kDa
• Protein Length: 615 amino acids
• AA Sequence: MAVYVGMLRL GRLCAGSSGV LGARAALSRS WQEARLQGVR FLSSREVDRM VSTPIGGLSY VQGCTKKHLN SKTVVQCLET TAQRVPEREA LVVLHEDVRL TFAQLKEEVD KAASGLLSIG LCKGDRLGMW GPNSYAWVLM QLATAQAGII LVSVNPAYQA MELEYVLKKV GCKALVFPKQ FKTQQYYNVL KQICPEVENA QPGALKSQRL PDLTTVISVD APLPGTLLLD EVVAAGSTRQ HLDQLQYNQQ FLSCHDPINI QFTSGTTGSP KGATLSHYNI VNNSNILGER LKLHEKTPEQ LRMILPNPLY HCLGSVAGTM MCLMYGATLI LASPIFNGKK ALEAISRERG TFLYGTPTMF VDILNQPDFS SYDISTMCGG VIAGSPAPPE LIRAIINKIN MKDLVVAYGT TENSPVTFAH FPEDTVEQKA ESVGRIMPHT EARIMNMEAG TLAKLNTPGE LCIRGYCVML GYWGEPQKTE EAVDQDKWYW TGDVATMNEQ GFCKIVGRSK DMIIRGGENI YPAELEDFFH THPKVQEVQV VGVKDDRMGE EICACIRLKD GEETTVEEIK AFCKGKISHF KIPKYIVFVT NYPLTISGKI QKFKLREQME RHLNL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACSF2 acyl-CoA synthetase family member 2 [ Homo sapiens ]
• Official Symbol: ACSF2
• Synonyms: ACSF2; acyl-CoA synthetase family member 2; acyl-CoA synthetase family member 2, mitochondrial; ACSMW; FLJ20920; PPARG binding, long chain fatty acid acyl Co-A ligase like; AVYV493
• Gene ID: 80221
• mRNA Refseq: NM_025149
• Protein Refseq: NP_079425
• MIM: 610465
• UniProt ID: Q96CM8

Reviews

10/07/2021

Super fast shipping and excellent customer service. Will definitely buy from again.

09/14/2021

Great product! Really satisfied with the quality of the recombinant protein.

07/13/2020

Wonderful product!

09/25/2018

Overall, I highly recommend this recombinant protein and the manufacturer for their excellent product and service.

08/21/2018

I was impressed with the strict quality control measures the manufacturer had in place to ensure consistent quality.

Q&As

Are there any therapeutic implications of targeting ACSF2?

ACSF2 inhibitors have been proposed as a potential therapeutic strategy for the treatment of metabolic disorders, although further research is needed to validate this approach.

What is the substrate specificity of ACSF2?

ACSF2 has a broad substrate specificity and can activate a range of long-chain fatty acids including palmitic acid, oleic acid, and arachidonic acid.

What is the mechanism of ACSF2-mediated fatty acid activation?

ACSF2 activates fatty acids by converting them into their acyl-CoA derivatives through the use of ATP and CoA.

What is the role of ACSF2 in cellular stress response?

ACSF2 has been shown to play a role in the cellular stress response by regulating the activation of AMPK and the expression of stress response genes.

What is the role of ACSF2 in cancer?

ACSF2 has been shown to play a role in tumor growth and progression in several types of cancer, including colorectal cancer and hepatocellular carcinoma.

Where is ACSF2 primarily expressed?

ACSF2 is highly expressed in the liver and also in other tissues such as the brain, heart, and muscle.

How does ACSF2 affect lipid droplet dynamics?

ACSF2 has been shown to play a role in the regulation of lipid droplet dynamics by regulating the activity of lipases and promoting the formation of lipid droplets.

What is the effect of ACSF2 overexpression on fatty acid metabolism?

Overexpression of ACSF2 has been shown to increase fatty acid oxidation and decrease fatty acid synthesis in hepatocytes.

How does ACSF2 affect insulin sensitivity?

ACSF2 has been shown to play a role in insulin sensitivity by regulating glucose uptake and lipid metabolism in skeletal muscle cells.

How is ACSF2 involved in the regulation of inflammation?

ACSF2 has been shown to regulate the production of inflammatory cytokines in macrophages and may play a role in the development of inflammatory diseases.