Recombinant Full Length Human ACY1 Protein, GST-tagged
Cat.No. : | ACY1-836HF |
Product Overview : | Human ACY1 full-length ORF ( AAH00545, 1 a.a. - 408 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 70.62 kDa |
Protein Length : | 408 amino acids |
AA Sequence : | MTSKGPAEEH PSVTLFRQYL RIRTVQPKPD YGAAVAFFEE TARQLGLGCQ KVEVAPGYVV TVLTWPGTNP TLSSILLNSH TDVVPVFKEH WSHDPFEAFK DSEGYIYARG AQDVKCVSIQ YLEAVRRLKV EGHRFPRTIH MTFVPDEEVG GHQGMELFVQ RPEFHALRAG FALDEGIANP TDAFTVFYSE RSPWWVRVTS TGRPGHASRF MEDTAAEKLH KVVNSILAFR EKEWQRLQSN PHLKEGSVTS VNLTKLEGGV AYNVIPATMS ASFDFRVAPD VDFKAFEEQL QSWCQAAGEG VTLEFAQKWM HPQVTPTDDS NPWWAAFSRV CKDMNLTLEP EIMPAATDNR YIRAVGVPAL GFSPMNRTPV LLHDHDERLH EAVFLRGVDI YTRLLPALAS VPALPSDS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ACY1 aminoacylase 1 [ Homo sapiens ] |
Official Symbol : | ACY1 |
Synonyms : | ACY1; aminoacylase 1; aminoacylase-1; acylase; N-acyl-L-amino-acid amidohydrolase; ACY-1; ACY1D |
Gene ID : | 95 |
mRNA Refseq : | NM_000666 |
Protein Refseq : | NP_000657 |
MIM : | 104620 |
UniProt ID : | Q03154 |
Products Types
◆ Recombinant Protein | ||
ACY1-1152H | Recombinant Human ACY1 Protein, DDK-tagged | +Inquiry |
Acy1-299M | Recombinant Mouse Acy1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACY1-242H | Recombinant Human ACY1 protein(Met1-Ser408), His-tagged | +Inquiry |
Acy1-424M | Recombinant Mouse Acy1 Protein, MYC/DDK-tagged | +Inquiry |
ACY1-153R | Recombinant Rat ACY1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACY1-725HCL | Recombinant Human ACY1 cell lysate | +Inquiry |
ACY1-3095MCL | Recombinant Mouse ACY1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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