Recombinant Full Length Human ADORA3 Protein

• Cat.No.: ADORA3-968HF
• Product Overview: Human ADORA3 full-length ORF (NP_000668.1) recombinant protein without tag.

Specification

• Description: This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 36.2 kDa
• Protein Length: 318 amino acids
• AA Sequence: MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC VVCHPSDSLD TSIEKNSE
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.

Gene Information

• Gene Name: ADORA3 adenosine A3 receptor [ Homo sapiens ]
• Official Symbol: ADORA3
• Synonyms: ADORA3; adenosine A3 receptor; adenosine receptor A3; AD026; A3AR; bA552M11.5; RP11-552M11.7
• Gene ID: 140
• mRNA Refseq: NM_000677
• Protein Refseq: NP_000668
• MIM: 600445
• UniProt ID: P0DMS8

Reviews

06/01/2021

Its excellent solubility and stability properties have given me confidence in its reliability.

10/17/2018

The purity and consistency of this protein have surpassed my expectations, making it an ideal choice for my research.

06/18/2018

the technical team has been extremely responsive and knowledgeable, offering valuable insights and solutions to any concerns I had.

Q&As

Are there any drugs currently on the market that target ADORA3 proteins?

There are currently no drugs available that specifically target ADORA3 proteins. However, there are drugs that target other adenosine receptors, such as caffeine (which blocks adenosine receptors), methylxanthines (which block both adenosine A1 and A2A receptors), and antiarrhythmic drugs (which target adenosine A1 receptors in the heart).

What are ADORA3 proteins?

ADORA3 proteins, also known as adenosine A3 receptors, are a subtype of adenosine receptors that are found in various tissues throughout the body including the brain, heart, lungs, liver, and immune cells. These receptors are responsible for mediating the effects of adenosine, a signaling molecule that regulates various physiological processes including inflammation, immune function, and cardiovascular function.

What are some challenges associated with developing drugs that target ADORA3 proteins?

One challenge is the potential for side effects, as these receptors are found in multiple tissues throughout the body and have diverse effects on various physiological processes. Therefore, drugs targeting ADORA3 proteins may have off-target effects on other tissues and systems. Additionally, ADORA3-targeting drugs may need to be developed with specific dosing strategies or combinations with other medications to be effective against certain diseases.