Recombinant Full Length Human ADPRHL1 Protein, GST-tagged
Cat.No. : | ADPRHL1-974HF |
Product Overview : | Human ADPRHL1 full-length ORF ( NP_612439.2, 1 a.a. - 354 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 66.5 kDa |
Protein Length : | 354 amino acids |
AA Sequence : | MEKFKAAMLL GSVGDALGYR NVCKENSTVG MKIQEELQRS GGLDHLVLSP GEWPVSDNTI MHIATAEALT TDYWCLDDLY REMVRCYVEI VEKLPERRPD PATIEGCAQL KPNNYLLAWH TPFNEKGSGF GAATKAMCIG LRYWKPERLE TLIEVSVECG RMTHNHPTGF LGSLCTALFV SFAAQGKPLV QWGRDMLRAV PLAEEYCRKT IRHTAEYQEH WFYFEAKWQF YLEERKISKD SENKAIFPDN YDAEEREKTY RKWSSEGRGG RRGHDAPMIA YDALLAAGNS WTELCHRAMF HGGESAATGT IAGCLFGLLY GLDLVPKGLY QDLEDKEKLE DLGAALYRLS TEEK |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ADPRHL1 ADP-ribosylhydrolase like 1 [ Homo sapiens ] |
Official Symbol : | ADPRHL1 |
Synonyms : | ADPRHL1; ADP-ribosylhydrolase like 1; [Protein ADP-ribosylarginine] hydrolase-like protein 1; ARH2; ADP-ribosyl-hydrolase; ADP-ribosylhydrolase 2 |
Gene ID : | 113622 |
mRNA Refseq : | NM_138430 |
Protein Refseq : | NP_612439 |
MIM : | 610620 |
UniProt ID : | Q8NDY3 |
Products Types
◆ Recombinant Protein | ||
ADPRHL1-360M | Recombinant Mouse ADPRHL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADPRHL1-193R | Recombinant Rat ADPRHL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ADPRHL1-376H | Recombinant Human ADPRHL2 Protein, GST-tagged | +Inquiry |
ADPRHL1-9439H | Recombinant Human ADPRHL1, His-tagged | +Inquiry |
ADPRHL1-1376M | Recombinant Mouse ADPRHL1 Protein | +Inquiry |
◆ Lysates | ||
ADPRHL1-9002HCL | Recombinant Human ADPRHL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (9)
Ask a questionADPRHL1 has been found to be overexpressed in several types of cancer cells, such as colon, breast, and lung cancer cells. Studies suggest that ADPRHL1 may promote cancer cell survival by modulating signaling pathways that regulate cell growth and apoptosis. Inhibition of ADPRHL1 has been shown to reduce cancer cell growth and sensitize cancer cells to chemotherapy, suggesting that ADPRHL1 may be a potential therapeutic target for cancer treatment.
Yes, there have been several genetic variants of ADPRHL1 identified that are associated with disease. For example, a single nucleotide polymorphism (SNP) in the ADPRHL1 gene has been linked to an increased risk of developing prostate cancer. Another SNP has been associated with an increased risk of developing schizophrenia. However, more research is needed to fully understand the links between ADPRHL1 genetic variants and disease.
There is some evidence to suggest that ADPRHL1 proteins may be useful as a biomarker for certain diseases. For example, elevated levels of ADPRHL1 have been found in the blood and cerebrospinal fluid of patients with Alzheimer's disease and Parkinson's disease, respectively. Additionally, ADPRHL1 has been proposed as a potential biomarker for early detection of breast cancer. However, further research is needed to confirm the clinical utility of ADPRHL1 as a biomarker for these and other diseases.
In addition to cancer, ADPRHL1 has been implicated in several other areas of medical research. For example, studies have suggested that ADPRHL1 plays a role in the regulation of glucose metabolism, and may be involved in the development of type 2 diabetes. Additionally, ADPRHL1 has been implicated in the regulation of inflammatory responses, and may be involved in the pathogenesis of autoimmune diseases such as rheumatoid arthritis and lupus. Further research is needed to fully understand the role of ADPRHL1 in these and other areas of medical research.
Yes, several genetic variants of the ADPRHL1 gene have been identified. These include single nucleotide polymorphisms (SNPs) that affect the expression and activity of the enzyme. For example, one study found that a common SNP in the ADPRHL1 gene is associated with an increased risk of breast cancer in women. Other studies have identified SNPs that are associated with the risk of developing type 2 diabetes and other metabolic disorders. Additionally, mutations in the ADPRHL1 gene have been linked to hereditary spastic paraplegia. These genetic variants may have important implications for disease risk and personalized medicine.
Yes, several compounds have been identified that inhibit the activity of ADPRHL1. One of the most potent inhibitors is 2-palmitoylisopropyl phosphoramidate (2-PIPA), which inhibits ADPRHL1 by covalently modifying a catalytic residue in the enzyme's active site. In addition, several other compounds have been identified through high-throughput screening and structure-based drug design approaches. These compounds often target specific structural features of the enzyme, such as the active site residues or the C-terminal domain, and may have potential therapeutic applications in the treatment of diseases such as Alzheimer's and Parkinson's.
ADPRHL1 protein levels can be measured in clinical settings using various laboratory techniques, such as ELISA or Western blotting. These techniques involve collecting a sample of blood, urine, or tissue from the patient, and then measuring the amount of ADPRHL1 protein present in the sample. These measurements can provide valuable information about the patient's health status and disease progression, and may be used to inform treatment decisions. However, these techniques are not routinely used in clinical practice and further research is needed to establish their clinical utility.
There are currently no drugs approved for the specific targeting of ADPRHL1. However, several studies have investigated the efficacy of ADPRHL1 inhibition as a potential cancer therapy. One study found that a small molecule inhibitor of ADPRHL1 reduced the growth of breast cancer cells in vitro and in vivo. Additionally, another study found that inhibiting ADPRHL1 enhanced the efficacy of chemotherapy in colorectal cancer cells. These findings suggest that ADPRHL1 inhibition may be a promising therapeutic strategy for cancer, but further research is needed to develop effective drugs that specifically target ADPRHL1.
Yes, ADPRHL1 has been implicated in several neurological diseases. Studies have found that the expression of ADPRHL1 is increased in the brains of patients with Alzheimer's disease and that ADPRHL1 may contribute to the development of the disease by promoting the accumulation of beta-amyloid. ADPRHL1 has also been proposed as a potential therapeutic target for Parkinson's disease, as its inhibition may help to prevent the loss of dopaminergic neurons in the brain. Additionally, mutations in the ADPRHL1 gene have been linked to hereditary spastic paraplegia, a rare neurodegenerative disorder that affects the lower limbs and causes progressive muscle weakness and spasticity.
Customer Reviews (5)
Write a reviewSince I needed a high purity protein, the manufacturer recommended ADPRHL1 based on its purity, and it did not disappoint.
Their attention to detail and responsiveness have made them a trusted partner in my scientific endeavors.
The ADPRHL1 protein I have acquired is of exceptional quality and meets all of my experimental requirements.
I am pleased with the excellent technical support provided by the manufacturer, which has helped me to overcome any technical issues and carry out my research with ease.
I am very satisfied with the product and the support provided by the manufacturer, and I highly recommend them to other researchers in the field.
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