Recombinant Full Length Human AHNAK2 Protein, GST-tagged

• Cat.No.: AHNAK2-949HF
• Product Overview: Human AHNAK2 full-length ORF ( AAH49216.1, 1 a.a. - 483 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a large nucleoprotein. The encoded protein has a tripartite domain structure with a relatively short N-terminus and a long C-terminus, separated by a large body of repeats. The N-terminal PSD-95/Discs-large/ZO-1 (PDZ)-like domain is thought to function in the formation of stable homodimers. The encoded protein may play a role in calcium signaling by associating with calcium channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 79.1 kDa
• Protein Length: 483 amino acids
• AA Sequence: MRLPETQVLP GEIDETPLSK PGHDLASMED KTEKWSSQPE GPLKLKASST DMPSQISVVN VDQLWEDSVL TVKFPKLMVP RFSFAAPSSE DDVFIPTVRE VQCPEANIDT ALCKESPGLW GASILKAGAG VPGEQPVDLN LPLEAPPISK VRVHIQGAQV ESQEVTIHSI VTPEFVDLSV PRTFSTQIVR ESEIPTSEIQ TPSYGFSLLK VKIPEPHTQA RVYTTMTQHS RTQEGTEEAP IQATPGVDSI SGDLQPDTGE PFEMISSSVN VLGQQTLTFE VPSGHQLADS CSDEEPAEIL EFPPDDSQEA TTPLADEGRA PKDKPESKKS GLLWFWLPNI GFSSSVDETG VDSKNDVQRS APIQTQPEAR PEAELPKKQE KAGWFRFPKL GFSSSPTKKS KSTEDGAELE EQKLQEETIT FFDARESFSP EEKEEGELIG PVGTGLDSRV MVTSAARTEL ILPEQDRKAD DESKGSGLGP NEG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AHNAK2 AHNAK nucleoprotein 2 [ Homo sapiens ]
• Official Symbol: AHNAK2
• Synonyms: AHNAK2; AHNAK nucleoprotein 2; C14orf78, chromosome 14 open reading frame 78; protein AHNAK2; C14orf78; KIAA2019
• Gene ID: 113146
• mRNA Refseq: NM_138420
• Protein Refseq: NP_612429
• MIM: 608570
• UniProt ID: Q8IVF2

Reviews

04/02/2022

Research success made simple with this lab protein.

01/17/2021

Our satisfaction with the lab protein product is resounding, and its contribution to our research achievements is profoundly appreciated.

05/01/2020

Researchers seeking a reliable and robust lab protein will find this product to be an exemplary addition to their experimental toolkit.

08/22/2019

This lab protein deserves a standing ovation – it's fantastic!

11/16/2018

The product's user-friendly nature has facilitated seamless integration into our protocols, leading to enhanced experimental outcomes.

Q&As

How is AHNAK2 expression regulated during cell cycle progression?

AHNAK2 expression levels may fluctuate during the cell cycle, with possible implications for cell cycle regulation and progression.

Can AHNAK2 be used as a diagnostic or prognostic marker for specific diseases?

AHNAK2 expression alterations have been observed in certain diseases, but its potential as a diagnostic or prognostic marker requires further clinical validation.

Are there any post-translational modifications that regulate AHNAK2 activity?

AHNAK2 can undergo phosphorylation and acetylation, which may modulate its interactions with other proteins and its subcellular localization.

How does AHNAK2 contribute to vesicle trafficking and organelle dynamics?

AHNAK2 interacts with proteins involved in vesicle transport and organelle dynamics, suggesting its role in intracellular trafficking processes.

Does AHNAK2 have any known involvement in cardiac physiology?

AHNAK2 has been implicated in cardiac functions, particularly in the heart's intercalated discs, suggesting a role in maintaining cardiac integrity.

What is the role of AHNAK2 in membrane repair processes?

AHNAK2 is recruited to sites of plasma membrane damage and participates in membrane resealing, contributing to cellular membrane repair mechanisms.

Can AHNAK2 modulate calcium signaling in a manner similar to AHNAK?

Yes, like AHNAK, AHNAK2 can interact with calcium-binding proteins, such as annexins, and influence calcium signaling pathways.

How does AHNAK2 participate in cell adhesion and migration processes?

AHNAK2 interacts with components of cell-matrix adhesions and the actin cytoskeleton, playing a role in stabilizing cell adhesion structures and regulating cell migration.

How is AHNAK2 expression regulated in different tissues and cell types?

AHNAK2 expression is tightly regulated by various transcription factors and epigenetic modifications, resulting in tissue-specific and cell type-specific expression patterns.

What are the primary cellular functions of AHNAK2?

AHNAK2 is involved in various cellular processes, including cell adhesion, membrane repair, calcium signaling, and regulation of the actin cytoskeleton.