Recombinant Full Length Human AHRR Protein, GST-tagged
Cat.No. : | AHRR-950HF |
Product Overview : | Human AHRR full-length ORF ( AAI60162.1, 1 a.a. - 719 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 79.1 kDa |
Protein Length : | 719 amino acids |
AA Sequence : | MPRTMIPPGE CTYAGRKRRR PLQKQRPAVG AEKSNPSKRH RDRLNAELDH LASLLPFPPD IISKLDKLSV LRLSVSYLRV KSFFQVVQEQ SSRQPAAGAP SPGDSCPLAG SAVLEGRLLL ESLNGFALVV SAEGTIFYAS ATIVDYLGFH QTDVMHQNIY DYIHVDDRQD FCRQLHWAMD PPQVVFGQPP PLETGDDAIL GRLLRAQEWG TGTPTEYSAF LTRCFICRVR CLLDSTSGFL ARGSQAWQLR LCCPEPLMTM QFQGKLKFLF GQKKKAPSGA MLPPRLSLFC IAAPVLLPSA AEMKMRSALL RAKPRADTAA TADAKVKATT SLCESELHGK PNYSAGRSSR ESGVLVLREQ TDAGRWAQVP ARAPCLCLRG GPDLVLDPKG GSGDREEEQH RMLSRASGVT GRRETPGPTK PLPWTAGKHS EDGARPRLQP SKNDPPSLRP MPRGSCLPCP CVQGTFRNSP ISHPPSPSPS AYSSRTSRPM RDVGEDQVHP PLCHFPQRSL QHQLPQPGAQ RFATRGYPME DMKLQGVPMP PGDLCGPTLL LDVSIKMEKD SGCEGAADGC VPSQVWLGAS DRSHPATFPT RMHLKTEPDS RQQVYISHLG HGVRGAQPHG RATAGRSREL TPFHPAHCAC LEPTDGLPQS EPPHQLCARG RGEQSCTCRA AEAAPVVKRE PLDSPQWATH SQGMVPGMLP KSALATLVPP QASGCTFLP |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AHRR aryl-hydrocarbon receptor repressor [ Homo sapiens ] |
Official Symbol : | AHRR |
Synonyms : | AHRR; aryl-hydrocarbon receptor repressor; AHH, AHHR, aryl hydrocarbon receptor regulator; aryl hydrocarbon receptor repressor; bHLHe77; KIAA1234; ahR repressor; dioxin receptor repressor; aryl hydrocarbon hydroxylase regulator; class E basic helix-loop-helix protein 77; AHH; AHHR; MGC167813; MGC176630 |
Gene ID : | 57491 |
mRNA Refseq : | NM_001242412 |
Protein Refseq : | NP_001229341 |
MIM : | 606517 |
UniProt ID : | A9YTQ3 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionGenetic variations in AHRR can lead to altered protein function and influence individual susceptibility to diseases influenced by the AHR signaling pathway, such as cancer and immune-related disorders.
AHRR expression can influence an individual's sensitivity to environmental carcinogens and toxicants by modulating AHR activity and downstream gene expression.
AHRR expression levels can vary among tissues and cell types, depending on the local microenvironment, exposure to specific ligands, and tissue-specific transcriptional regulators.
AHRR contains domains that enable its interaction with AHR, such as bHLH (basic helix-loop-helix) and PAS (Per-Arnt-Sim) domains, facilitating the formation of inhibitory complexes with AHR.
AHRR acts as a negative regulator of the AHR signaling pathway, inhibiting AHR-mediated gene transcription in response to ligand activation.
AHRR competes with AHR for binding to the same target genes, effectively blocking AHR-mediated transcription and inhibiting the expression of AHR-responsive genes.
AHRR is implicated in modulating inflammatory responses and immune cell differentiation, affecting the balance between pro-inflammatory and anti-inflammatory signals.
AHRR expression can be induced by various environmental stimuli, such as exposure to AHR ligands and other stressors. Transcription factors and epigenetic modifications can regulate AHRR gene expression.
AHRR plays a crucial role in regulating the expression of genes involved in xenobiotic metabolism and detoxification, contributing to the body's defense against environmental toxins.
AHRR is involved in circadian rhythm regulation and contributes to metabolic homeostasis by influencing the expression of clock genes and metabolic regulators.
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