Recombinant Full Length Human ALOX15 Protein, GST-tagged

• Cat.No.: ALOX15-1479HF
• Product Overview: Human ALOX15 full-length ORF ( AAH29032, 1 a.a. - 662 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include Periventricular Leukomalacia and Artery Disease. Among its related pathways are Arachidonic acid metabolism and HETE and HPETE biosynthesis and metabolism. GO annotations related to this gene include iron ion binding and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. An important paralog of this gene is ALOX12.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 98.56 kDa
• Protein Length: 662 amino acids
• AA Sequence: MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY PQDALRLWEI IYRYVEGIVS LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV AI
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALOX15 arachidonate 15-lipoxygenase [ Homo sapiens ]
• Official Symbol: ALOX15
• Synonyms: ALOX15; arachidonate 15-lipoxygenase; 15 LOX 1; 15-LOX; 15-lipooxygenase-1; arachidonate omega-6 lipoxygenase; 15LOX-1; 15-LOX-1
• Gene ID: 246
• mRNA Refseq: NM_001140
• Protein Refseq: NP_001131
• MIM: 152392
• UniProt ID: P16050

Reviews

12/19/2022

Good fluorescence and absorption properties.

11/26/2021

ALOX15 has good stability in different environments and is not easily degraded.

08/26/2021

The effects of the recombinant proteins on the pathogenesis of related diseases were evaluated by animal models or in vitro experiments and found to be very good.

03/11/2021

The catalytic activity of ALOX15 protein is very excellent, and it can efficiently promote the progress of chemical reactions, showing excellent catalytic performance.

Q&As

In what way does ALOX15 regulate cell proliferation?

It can regulate cell proliferation by regulating various cell signaling pathways and influencing cell cycle.

How does oxidative stress initiated by ALOX15 participate in immune response?

The oxidative stress response initiated by ALOX15 can induce cells to secrete a variety of cytokines, thus participating in the immune response.

What is the effect of ALOX15 and GSTP1 gene variation on chemotherapy response of BLCA patients?

ALOX15 and GSTP1 gene variants may affect how well BLCA patients respond to chemotherapy.

What effect does the loss of ALOX15 have on the body?

ALOX15 deficiency may lead to a variety of effects such as alveolar hyperdilation, cardiomyopathy, and metabolic syndrome.

Which cell signaling pathways are involved in ALOX15?

ALOX15 is involved in many cell signaling pathways, such as PI3K/AKT pathway, MAPK pathway, NF-κB pathway, etc.

What inflammatory reactions does ALOX15 participate in?

ALOX15 is involved in a variety of inflammatory reactions, such as asthma, arthritis, and skin inflammation.

What is the role of ALOX15 in asthma?

ALOX15 is involved in the pathogenesis of asthma, mediating airway stenosis and inflammation through the synthesis of leukotrienes.

What is the role of ALOX15 in tumorigenesis and development?

The effects of ALOX15 vary in different tumor types, such as acting as an inhibitor in colorectal cancer and promoting tumor cell growth and invasion in prostate cancer.

How does ALOX15 regulate apoptosis?

ALOX15 can affect apoptosis by regulating ROS levels and influencing cell signaling pathways.

What diseases do mutations in ALOX15 cause?

Mutations in ALOX15 have been linked to diseases such as asthma and Behcet's disease.

What is the role of ALOX15 in neurodevelopment?

This protein is involved in the process of neural development, such as promoting the growth of nerve cells and affecting brain development.

How does the oxidative stress response initiated by ALOX15 affect cell function?

Oxidative stress response initiated by ALOX15 produces a large number of ROS, which affects various cell functions, such as apoptosis and cell proliferation.

In what diseases does ALOX15 play a role?

It is involved in the pathogenesis of many diseases, such as asthma, rheumatoid arthritis, and skin inflammation.

What role does ALOX15 play in the function of keratinocytes?

It is involved in various functions such as keratinocyte differentiation and cell cycle regulation.