Recombinant Full Length Human ALOX15B Protein, GST-tagged

• Cat.No.: ALOX15B-1480HF
• Product Overview: Human ALOX15B full-length ORF ( AAH35217.1, 1 a.a. - 676 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 102.3 kDa
• Protein Length: 676 amino acids
• AA Sequence: MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNRGLVL PYTYLDPPLI ENSVSI
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ALOX15B arachidonate 15-lipoxygenase, type B [ Homo sapiens ]
• Official Symbol: ALOX15B
• Synonyms: ALOX15B; arachidonate 15-lipoxygenase, type B; arachidonate 15 lipoxygenase, second type; arachidonate 15-lipoxygenase B; 15 LOX 2; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; arachidonate omega(6) lipoxygenase; arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; 15-LOX-2
• Gene ID: 247
• mRNA Refseq: NM_001039130
• Protein Refseq: NP_001034219
• MIM: 603697
• UniProt ID: O15296

Reviews

05/22/2022

By using this recombinant protein, the efficiency of my experiments was significantly improved, and unnecessary waste of time was also reduced.

06/21/2021

I appreciate the attention paid to product quality by this recombinant protein manufacturer, and their recombinant proteins are very stable, which makes our experiments smoother.

03/06/2020

The catalytic activity of this protein is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.

09/22/2019

The reproducibility of the Western blot was significantly improved using this recombinant protein.

Q&As

Does ALOX15B mutation cause autoimmune diseases?

Yes, certain ALOX15B gene mutations are closely associated with the onset of several autoimmune diseases.

What is the relationship between the expression level of ALOX15B in tumors and patient prognosis?

The expression level of ALOX15B in tumors is closely related to the treatment response and prognosis of patients.

What is the relationship between ALOX15B and diseases related to blood circulation system?

Whether ALOX15B is related to the occurrence of diseases related to the blood circulation system (such as heart disease, thrombosis, etc.) still needs further research.

What diseases will be caused if the ALOX15B gene is mutated?

Mutations in ALOX15B can lead to a variety of diseases, such as asthma and autoimmune diseases.

Does ALOX15B have application prospects in the treatment of skin diseases?

Yes, ALOX15B may be a target for the treatment of certain skin diseases.

How does the expression level of ALOX15B in patients with asthma correlate with the severity of the disease?

Studies have shown that the level of ALOX15B expression in asthma patients is positively correlated with the severity of the disease.

Does ALOX15B participate in the systemic inflammatory response of asthma?

Yes, ALOX15B can promote an increased systemic inflammatory response in patients with asthma.

Does ALOX15B have potential application value in the treatment of tumors?

Yes, some studies suggest that ALOX15B has the potential to be a new target for tumor therapy.

Is ALOX15B involved in tumor growth and development?

Yes, ALOX15B is associated with the occurrence, development and metastasis of various cancers.

What is the role of ALOX15B in the human body?

The enzyme encoded by ALOX15B is mainly involved in the metabolism of arachidonic acid (AA), which is closely related to biological processes such as inflammation and immune regulation.

What is the relationship between ALOX15B and asthma?

Many experimental studies have shown that ALOX15B is closely related to the pathogenesis and pathophysiological mechanism of asthma.

What is the role of ALOX15B in angiogenesis?

ALOX15B can inhibit angiogenesis and thus play a role in tumor growth and metastasis.

Is ALOX15B involved in the onset and progression of skin diseases?

Yes, ALOX15B is closely related to the onset and progression of many skin diseases (such as psoriasis, psoriasis, etc.).