Recombinant Full Length Human AMBN Protein

• Cat.No.: AMBN-17HF
• Product Overview: Recombinant Full Length Human AMBN with N terminal proprrietary tag; Predicted MW 75.24kDa.

Specification

• Description: This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene cluster on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 75.240kDa inclusive of tags
• Protein Length: 447 amino acids
• AA Sequence: MSASKIPLFK MKDLILILCL LEMSFAVPFF PQQSGTPGMA SLSLETMRQL GSLQRLNTLS QYSRYGFGKS FNSLWMHGLL PPHSSLPWMR PREHETQQYE YSLPVHPPPL PSQPSLKPQQ PGLKPFLQSA AATTNQATAL KEALQPPIHL GHLPLQEGEL PLVQQQVAPS DKPPKPELPG VDFADPQGPS LPGMDFPDPQ GPSLPGLDFA DPQGSTIFQI ARLISHGPMP QNKQSPLYPG MLYVPFGANQ LNAPARLGIM SSEEVAGGRE DPMAYGAMFP GFGGMRPGFE GMPHNPAMGG DFTLEFDSPV AATKGPENEE GGAQGSPMPE ANPDNLENPA FLTELEPAPH AGLLALPKDD IPGLPRSPSG KMKGLPSVTP AAADPLMTPE LADVYRTYDA DMTTSVDFQE EATMDTTMAP NSLQTSMPGN KAQEPEMMHD AWHFQEP
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents: 0.3% Glutathione, 0.79% Tris HCl.

Gene Information

• Gene Name: AMBN ameloblastin (enamel matrix protein) [ Homo sapiens ]
• Official Symbol: AMBN
• Synonyms: AMBN; ameloblastin (enamel matrix protein); ameloblastin, enamel matrix protein; ameloblastin
• Gene ID: 258
• mRNA Refseq: NM_016519
• Protein Refseq: NP_057603
• MIM: 601259
• UniProt ID: Q9NP70

Reviews

08/09/2022

Reduced assay interference from complex sample backgrounds.

02/20/2022

High-throughput screening compatibility for rapid data generation.

08/17/2020

Reliable detection of protein localization and trafficking.

Q&As

Can AMBN be used as a biomarker for enamel defects or dental disorders, and what are the diagnostic implications of its expression patterns?

AMBN expression patterns and levels can serve as biomarkers for enamel defects or dental disorders, providing diagnostic information about the integrity and quality of the enamel layer.

Can AMBN-derived peptides or fragments be used as therapeutic agents for enamel repair or regeneration?

AMBN-derived peptides or fragments may have potential as therapeutic agents for enamel repair or regeneration, promoting enamel formation or stimulating the differentiation of dental stem cells.

How does AMBN contribute to the mechanical properties of enamel, such as hardness, resilience, and resistance to wear?

AMBN contributes to the mechanical properties of enamel, such as its hardness, resilience, and resistance to wear, through its organization and interaction with other enamel proteins.

What are the consequences of AMBN mutations or genetic variations on enamel formation and tooth integrity, and how do these variations contribute to dental phenotypes or disorders?

Mutations or genetic variations in the AMBN gene can lead to enamel defects and dental phenotypes, highlighting the importance of AMBN in enamel formation and integrity.

What are the post-translational modifications of AMBN, such as phosphorylation or glycosylation, and how do these modifications influence its function and assembly into the developing enamel matrix?

AMBN undergoes post-translational modifications, including phosphorylation and glycosylation, which play a role in its functional properties and assembly into the developing enamel matrix.

What are the mechanisms underlying AMBN secretion and transport to the enamel matrix, and how can these processes be modulated for therapeutic interventions in enamel-related disorders?

The secretion and transport of AMBN to the enamel matrix involve specific mechanisms, including vesicular trafficking and protein-protein interactions, which can be targeted for therapeutic interventions in enamel-related disorders.

How does AMBN interact with dental stem cells or progenitor cells, and what is its role in tooth regeneration or repair processes?

AMBN interacts with dental stem cells or progenitor cells, influencing their differentiation and contributing to tooth regeneration or repair processes.

What are the key signaling pathways or regulatory factors that control AMBN expression and secretion during tooth development?

The expression and secretion of AMBN during tooth development are regulated by various signaling pathways, including those involving transcription factors, growth factors, and extracellular matrix components.

How does AMBN interact with other enamel matrix proteins, such as amelogenin and enamelin, and what are the functional consequences of these interactions?

AMBN interacts with other enamel matrix proteins, such as amelogenin and enamelin, forming a complex network that contributes to the formation of the enamel matrix and its subsequent mineralization.

What is the role of AMBN in enamel development, and how does it contribute to enamel mineralization and structure?

AMBN is a critical protein involved in enamel development and is responsible for regulating enamel mineralization and determining the structure and hardness of the enamel layer.