Recombinant Full Length Human AMBP Protein, C-Flag-tagged
Cat.No. : | AMBP-882HFL |
Product Overview : | Recombinant Full Length Human AMBP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 37.1 kDa |
AA Sequence : | MRSLGALLLLLSACLAVSAGPVPTP PDNIQVQENFNISRIYGKWYNLAIG STCPWLKKIMDRMTVSTLVL GEGATEAEISMTSTRWRKGVCEETS GAYEKTDTDGKFLYHKSKWNITMES YVVHTNYDEYAIFLTKKFSR HHGPTITAKLYGRAPQLRETLLQDF RVVAQGVGIPEDSIFTMADRGECVP GEQEPEPILIPRVRRAVLPQ EEEGSGGGQLVTEVTKKEDSCQLGY SAGPCMGMTSRYFYNGTSMACETFQ YGGCMGNGNNFVTEKECLQT CRTVAACNLPIVRGPCRAFIQLWAF DAVKGKCVLFPYGGCQGNGNKFYSE KECREYCGVPGDGDEELLRF SNTRTRPLEQKLISEEDLAANDILD YKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Secreted Protein |
Gene Name : | AMBP alpha-1-microglobulin/bikunin precursor [ Homo sapiens (human) ] |
Official Symbol : | AMBP |
Synonyms : | A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC |
Gene ID : | 259 |
mRNA Refseq : | NM_001633.4 |
Protein Refseq : | NP_001624.1 |
MIM : | 176870 |
UniProt ID : | P02760 |
Products Types
◆ Recombinant Protein | ||
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AMBP-331H | Recombinant Human AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
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AMBP-302R | Recombinant Rat AMBP Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
AMBP-5312H | Native Human Alpha-1-Microglobulin/Bikunin Precursor | +Inquiry |
AMBP-27H | Native Human AMBP | +Inquiry |
◆ Lysates | ||
AMBP-001HCL | Recombinant Human AMBP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMBP expression levels and isoform variations can serve as diagnostic biomarkers for inflammatory diseases, immune dysregulation, or infection, aiding in disease diagnosis, monitoring, and prognostication.
AMBP expression is regulated by genetic and epigenetic factors, including transcription factors, DNA methylation, and histone modifications, which influence its expression patterns in different cell types and disease contexts.
AMBP modulates immune cell activities by regulating cellular adhesion, migration, phagocytosis, cytokine production, and immune cell differentiation through intracellular signaling pathways, such as MAPK and NF-魏B pathways.
AMBP participates in the regulation of complement activation by interacting with complement components, controlling the formation of membrane attack complexes and modulating the inflammatory response.
Targeting AMBP for therapeutic interventions in immune-mediated disorders or inflammatory conditions can be achieved through approaches such as small molecule inhibitors, antibody-based therapies, or gene editing techniques.
AMBP plays important roles in the immune system, including regulating inflammatory responses, modulating complement activation, and contributing to host defense mechanisms.
AMBP is released or secreted by immune cells through various mechanisms, including vesicular trafficking, exosomes, or proteolytic cleavage, which can be exploited for therapeutic purposes or biomarker discovery.
AMBP contributes to tissue homeostasis and immune surveillance in different organs, such as the kidney, lung, or reproductive system, and its dysregulation can have implications in tissue damage, autoimmune diseases, or infections in specific organ systems.
AMBP interacts with various immune-related proteins, such as complement components C3 and C5, cytokines, and cell surface receptors, influencing immune cell functions, immune signaling, and inflammation processes.
The structural features of AMBP, including its two domains (伪1-microglobulin and bikunin), are crucial for its immune-related functions, protein-protein interactions, and stability.
Customer Reviews (3)
Write a reviewCompatibility with various protein modification detection methods.
Enhanced data reproducibility in protein quantification.
Comprehensive profiling of protein expression patterns.
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