Recombinant Full Length Human AMIGO2 Protein, GST-tagged

• Cat.No.: AMIGO2-1307HF
• Product Overview: Human AMIGO2 full-length ORF ( NP_862830.1, 1 a.a. - 522 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: AMIGO2 (Adhesion Molecule With Ig Like Domain 2) is a Protein Coding gene. Diseases associated with AMIGO2 include Gastric Adenocarcinoma. An important paralog of this gene is AMIGO1.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 84.3 kDa
• Protein Length: 522 amino acids
• AA Sequence: MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST RGKSDSDSVN SVFSDTPFVA ST
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AMIGO2 adhesion molecule with Ig-like domain 2 [ Homo sapiens ]
• Official Symbol: AMIGO2
• Synonyms: AMIGO2; adhesion molecule with Ig-like domain 2; amphoterin-induced protein 2; ALI1; amphoterin induced gene and open reading frame 2; DEGA; alivin 1; amphoterin induced gene 2; transmembrane protein AMIGO2; differentially expressed in gastric adenocarcinoma; differentially expressed in gastric adenocarcinomas; AMIGO-2
• Gene ID: 347902
• mRNA Refseq: NM_181847
• Protein Refseq: NP_862830
• MIM: 615690
• UniProt ID: Q86SJ2

Reviews

05/17/2021

Versatility in multiple assay formats and platforms.

09/24/2020

Excellent reproducibility in protein expression profiling.

11/02/2017

Stable reagents for long-term storage and repeated use.

Q&As

Is there a correlation between AMIGO2 expression levels and neurological disorders?

Altered expression or dysregulation of AMIGO2 has been associated with neurological disorders, including autism spectrum disorders and epilepsy, highlighting its potential role in disease pathogenesis.

What is the expression pattern of AMIGO2 in the developing and adult brain?

AMIGO2 exhibits a dynamic expression pattern in the developing and adult brain, with high expression in regions involved in neuronal development, such as the cortex, hippocampus, and cerebellum.

What are the functional consequences of AMIGO2 knockout or overexpression in neuronal development and function?

Knockout or overexpression studies of AMIGO2 have revealed its essential role in neuronal development and function, impacting processes such as neurite outgrowth, synaptogenesis, and neuronal survival.

Can AMIGO2 modulate synaptic plasticity and neurotransmission?

AMIGO2 is involved in modulating synaptic plasticity and neurotransmission, regulating the activity and surface expression of neurotransmitter receptors and contributing to the refinement of synaptic connectivity.

How does AMIGO2 influence dendritic arborization and synaptic connectivity?

AMIGO2 influences dendritic arborization and synaptic connectivity, promoting dendritic branching and the formation of mature dendritic spines, which are crucial for synaptic transmission and plasticity.

Does AMIGO2 play a role in myelination and oligodendrocyte development?

AMIGO2 plays a role in myelination and oligodendrocyte development, contributing to proper myelin sheath formation and the maturation of oligodendrocytes.

Can manipulation of AMIGO2 expression or activity be a potential therapeutic approach for neurological conditions?

Modulation of AMIGO2 expression or activity holds potential as a therapeutic approach for neurological conditions, and further investigation into its specific mechanisms and interactions may unveil novel strategies for intervention and treatment.

What is the role of AMIGO2 in axon guidance and pathfinding?

AMIGO2 is involved in axon guidance and pathfinding, guiding axons to their appropriate targets during neuronal development, and contributing to the establishment of neuronal circuitry.

How does AMIGO2 contribute to neuronal migration during brain development?

AMIGO2 plays a critical role in neuronal migration during brain development, regulating the proper positioning and layering of neurons in the developing cerebral cortex.

Does AMIGO2 interact with other cell adhesion molecules or signaling proteins, and what are the downstream signaling pathways involved?

AMIGO2 interacts with various cell adhesion molecules and signaling proteins, including members of the immunoglobulin superfamily and growth factor receptors, activating downstream signaling pathways involved in cell adhesion, cytoskeletal remodeling, and synaptic plasticity.