Recombinant Full Length Human AP1B1 Protein, GST-tagged

• Cat.No.: AP1B1-1013HF
• Product Overview: Human AP1B1 full-length ORF ( CAK54367.1, 1 a.a. - 939 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 129.69 kDa
• Protein Length: 939 amino acids
• AA Sequence: MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG GGLDSLIGGT NFVAPPTAAV PANLGAPIGS GLSDLFDLTS GVGTLSGSYV APKAVWLPAM KAKGLEISGT FTRQVGSISM DLQLTNKALQ VMTDFAIQFN RNSFGLAPAA PLQVHAPLSP NQTVEISLPL STVGSVMKME PLNNLQVAVK NNIDVFYFST LYPLHILFVE DGKMDRQMFL ATWKDIPNEN EAQFQIRDCP LNAEAASSKL QSSNIFTVAK RNVEGQDMLY QSLKLTNGIW VLAELRIQPG NPSCTLSLKC RAPEVSQHVY QAYETILKN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AP1B1 adaptor-related protein complex 1, beta 1 subunit [ Homo sapiens ]
• Official Symbol: AP1B1
• Synonyms: AP1B1; adaptor-related protein complex 1, beta 1 subunit; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; BAM22; beta1-adaptin; beta-1-adaptin; beta-adaptin 1; beta-prime-adaptin; Golgi adaptor HA1/AP1 adaptin beta subunit; adaptor protein complex AP-1 subunit beta-1; adapter-related protein complex 1 subunit beta-1; clathrin assembly protein complex 1 beta large chain; plasma membrane adaptor HA2/AP2 adaptor beta subunit; ADTB1; CLAPB2
• Gene ID: 162
• mRNA Refseq: NM_001127
• Protein Refseq: NP_001118
• MIM: 600157
• UniProt ID: Q10567

Reviews

10/11/2022

Reproducibility of the AP1B1 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.

11/07/2020

AP1B1 labeling effect is very good, can be used for fluorescence labeling, etc., which is very suitable for our research.

03/30/2020

It is very stable, even after multiple uses or storage, its structure and function remain stable, providing strong support for long-term experiments and applications.

05/21/2019

Catalytic activity of this protein is very strong, which can make chemical reactions that are difficult to carry out easy to achieve, and has high application potential.

Q&As

Does AP1B1 mutation cause vision problems?

AP1B1 mutations may be associated with retinal diseases, but there are relatively few studies directly related to vision problems.

Is AP1B1 mutation associated with mental illness?

Some studies have shown that the AP1B1 gene mutation may be associated with some mental diseases such as schizophrenia.

What is the effect of AP1B1 mutation on treatment?

AP1B1 mutation may affect intracellular vesicle transport and membrane protein localization, thus affecting the efficacy of therapy and the action of drugs.

Is AP1B1 mutation related to intelligence development?

Some studies have shown that mutations in the AP1B1 gene may be associated with diseases related to intellectual development.

What diseases are associated with AP1B1 mutations?

AP1B1 mutations may be associated with a variety of diseases, including congenital retinitis pigmentosa and neurodegenerative diseases.

Can AP1B1 mutation be repaired by gene editing?

Gene-editing techniques such as CRISPR-Cas9 could potentially be used to fix AP1B1 mutations, but they are still in the laboratory stage and require further research and trials.

Can AP1B1 mutations be inherited?

AP1B1 mutation may be hereditary, and the specific inheritance pattern may be related to each specific mutation.

How to treat diseases caused by AP1B1 mutations?

There is currently no specific treatment for diseases caused by AP1B1 mutations, but the quality of life of patients can be improved through symptom relief treatment and rehabilitation training.

What is the function of AP1B1?

AP1B1 plays an important role in cell regulation by participating in intracellular vesicle transport and cell membrane protein localization.

How does AP1B1 mutation affect intracellular signaling?

AP1B1 mutation may lead to the abnormality of intracellular signal transduction pathway and affect the normal process of various biochemical reactions in the cell.

How can AP1B1 mutation be prevented?

There is currently no direct way to prevent AP1B1 mutations, but a healthy lifestyle and genetic counseling may help reduce the risk of certain genetic diseases.

What is the latest progress of AP1B1 research?

Recent studies have shown that AP1B1 plays an important role in intracellular vesicle transport and neuronal development.

Does AP1B1 mutation affect life span?

It is unclear whether AP1B1 mutations directly affect longevity.

How to detect AP1B1 gene mutation?

AP1B1 gene mutation can be detected by molecular biological methods such as gene sequencing.