Recombinant Full Length Human Aquaporin-12B(Aqp12B) Protein, His-Tagged

• Cat.No.: RFL-22332HF
• Product Overview: Recombinant Full Length Human Aquaporin-12B(AQP12B) Protein (A6NM10) (1-295aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length (1-295)
• AA Sequence: MAGLNVSLSFFFATFTLCEAARRAS KALLPVGAYEVFAREAMRTLVELGP WAGDFGPDLLLTLLFLLFLAHGVTL DGASANPTVSLQEFLMAEESLPGTL LKLAAQGLGMQAACTLTRLCWAWEL SDLHLLQSLMAQSCSSALRTSVPHG ALVEAACAFCFHLTLLHLRHSPPAY SGPAVALLVTVTAYTAGPFTSAFFN PALAASVTFACSGHTLLEYVQVYWL GPLTGMVLAVLLHQGRLPHLFQRNL FYGQKNKYRAPRGKPAPASGDTQTP AKGSSVREPGRSGVEGPHSS
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: AQP12B
• Synonyms: AQP12B; Aquaporin-12B; AQP-12B
• UniProt ID: A6NM10

Gene Information

• Gene Name: AQP12B
• Synonyms: AQP12B; Aquaporin-12B; AQP-12B
• UniProt ID: A6NM10

Reviews

01/03/2022

If the need arises for larger quantities of AQP12B protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.

12/04/2020

The manufacturer not only ensures the provision of superior protein but also aids researchers with their solid technical support, offering the necessary resources to optimize experimental protocols.

03/25/2019

the AQP12B protein offers numerous advantages for researchers conducting trials due to its high quality and stability.

12/29/2016

manufacturers or suppliers of proteins can play a crucial role in supporting researchers during trials.

03/03/2016

the manufacturer of AQP12B protein provides excellent technical support, ensuring prompt assistance and guidance.

Q&As

Are there any known genetic variations or mutations in the AQP12B gene?

Limited information is available regarding genetic variations or mutations in the AQP12B gene. More research is needed to identify any potential genetic variants that may be associated with certain phenotypes or diseases.

Are there any known genetic variations or mutations in the AQP12B gene?

Limited information is available regarding genetic variations or mutations in the AQP12B gene. More research is needed to identify any potential genetic variants that may be associated with certain phenotypes or diseases.

Can changes in AQP12B expression or function impact water balance in the body?

As AQP12B is believed to play a role in water transport in the gastrointestinal tract, changes in its expression or function may potentially affect water balance in the body, particularly in the digestive system. However, further research is needed to establish a clearer understanding of its impact on overall water balance.

How does AQP12B differ from other aquaporin proteins?

AQP12B is part of the aquaporin protein family, which includes various members involved in water transport. The main difference is that AQP12B has distinctive structural features and distinct gene expression patterns compared to other aquaporins. Its specific functions and properties also vary from other aquaporin proteins.

How does AQP12B differ from other aquaporin proteins?

AQP12B is part of the aquaporin protein family, which includes various members involved in water transport. The main difference is that AQP12B has distinctive structural features and distinct gene expression patterns compared to other aquaporins. Its specific functions and properties also vary from other aquaporin proteins.

Are there any ongoing clinical trials focusing on AQP12B?

As of now, there are no ongoing clinical trials specifically targeting AQP12B. However, ongoing research in the field of gastrointestinal physiology and related disorders may indirectly contribute to understanding the role of AQP12B.

Are there any pharmacological interventions that can modulate AQP12B activity?

Currently, there are no known pharmacological interventions or drugs specifically targeting AQP12B activity. Further research is needed to identify potential modulators or regulators of its function.

What are the future research directions for AQP12B?

Future research on AQP12B may focus on characterizing its transport properties, unraveling its role in gastrointestinal physiology and pathology, identifying its potential interactions with other proteins, and exploring its involvement in diseases or disorders related to water and small molecule transport.

What are the future research directions for AQP12B?

Future research on AQP12B may focus on characterizing its transport properties, unraveling its role in gastrointestinal physiology and pathology, identifying its potential interactions with other proteins, and exploring its involvement in diseases or disorders related to water and small molecule transport.

Is AQP12B expressed in other tissues besides the gastrointestinal tract?

Studies have shown that AQP12B is primarily expressed in the small intestine and colon, suggesting its role in gastrointestinal water transport. Its expression in other tissues has not been widely investigated yet.

Are there any known AQP12B inhibitors or activators?

Currently, there are no specific known inhibitors or activators of AQP12B. The lack of research on AQP12B makes it challenging to identify modulators that can selectively affect its function. Further studies are needed to explore potential agents that can regulate its activity.

Are there any known AQP12B inhibitors or activators?

Currently, there are no specific known inhibitors or activators of AQP12B. The lack of research on AQP12B makes it challenging to identify modulators that can selectively affect its function. Further studies are needed to explore potential agents that can regulate its activity.

Is AQP12B associated with any diseases or disorders?

Currently, there is limited information on the association of AQP12B with specific diseases or disorders. Further research is needed to explore its potential role in various physiological and pathological processes.

Is AQP12B involved in the absorption or secretion of other molecules besides water?

While the primary role of AQP12B is thought to be water transport, studies suggest that it may also transport small molecules other than water. However, the specific molecules and mechanisms involved require further investigation.

Is AQP12B involved in the absorption or secretion of other molecules besides water?

While the primary role of AQP12B is thought to be water transport, studies suggest that it may also transport small molecules other than water. However, the specific molecules and mechanisms involved require further investigation.

How does AQP12B expression change in response to different stimuli or conditions?

The regulation of AQP12B expression in response to various stimuli or conditions is not well understood. Hormones, cytokines, and other environmental factors may potentially influence its expression, but further research is necessary to fully elucidate its regulatory mechanisms.

How does AQP12B expression change in response to different stimuli or conditions?

The regulation of AQP12B expression in response to various stimuli or conditions is not well understood. Hormones, cytokines, and other environmental factors may potentially influence its expression, but further research is necessary to fully elucidate its regulatory mechanisms.