Recombinant Full Length Human Aquaporin-3(Aqp3) Protein, His-Tagged
Cat.No. : | RFL6229HF |
Product Overview : | Recombinant Full Length Human Aquaporin-3(AQP3) Protein (Q92482) (1-292aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Homo sapiens (Human) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-292) |
AA Sequence : | MGRQKELVSRCGEMLHIRYRLLRQA LAECLGTLILVMFGCGSVAQVVLSR GTHGGFLTIN LAFGFAVTLGILIAGQVSGAHLNPA VTFAMCFLAREPWIKLPIYTLAQTL GAFLGAGIVF GLYYDAIWHFADNQLFVSGPNGTAG IFATYPSGHLDMINGFFDQFIGTAS LIVCVLAIVD PYNNPVPRGLEAFTVGLVVLVIGTS MGFNSGYAVNPARDFGPRLFTALAG WGSAVFTTGQ HWWWVPIVSPLLGSIAGVFVYQLMI GCHLEQPPPSNEEENVKLAHVKHKE QI |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | AQP3 |
Synonyms : | AQP3; Aquaporin-3; AQP-3; Aquaglyceroporin-3 |
UniProt ID : | Q92482 |
Gene Name : | AQP3 |
Synonyms : | AQP3; Aquaporin-3; AQP-3; Aquaglyceroporin-3 |
UniProt ID : | Q92482 |
Products Types
◆ Recombinant Protein | ||
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AQP3-202R | Recombinant Rhesus Macaque AQP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Aqp3-235M | Recombinant Mouse Aqp3 Protein, His&GST-tagged | +Inquiry |
AQP3-649M | Recombinant Mouse AQP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AQP3-368H | Recombinant Human AQP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AQP3-8767HCL | Recombinant Human AQP3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionYes, mutations or alterations in the AQP3 gene have been associated with several skin disorders, including palmoplantar keratoderma and porokeratosis. These conditions are characterized by abnormal skin thickening and the formation of scaly patches.
Yes, genetic testing can be conducted to identify mutations in the AQP3 gene that may be associated with specific skin disorders. This testing can help with diagnosis and provide valuable information for understanding the underlying cause of the condition.
Yes, certain lifestyle factors and environmental conditions can influence AQP3 activity. For example, exposure to ultraviolet radiation from sunlight can upregulate AQP3 expression in the skin, potentially affecting skin hydration and barrier function. Additionally, some studies suggest that certain drugs, such as retinoids, may modulate AQP3 expression and function.
AQP3 dysfunction may be involved in the development of some metabolic disorders and certain types of cancer. Dysregulation of AQP3 expression or activity has been linked to altered water transport and cell proliferation, which can contribute to disease progression.
While AQP3 primarily functions as a water transporter, there is evidence suggesting its involvement in thermoregulation. Studies have shown that AQP3 expression increases in response to heat exposure, and it may facilitate the movement of water and thermal energy across the skin, contributing to cooling mechanisms in the body.
While AQP3 primarily functions as a water transporter, there is evidence suggesting its involvement in thermoregulation. Studies have shown that AQP3 expression increases in response to heat exposure, and it may facilitate the movement of water and thermal energy across the skin, contributing to cooling mechanisms in the body.
AQP3 has been investigated as a potential therapeutic target in various contexts. For example, in dermatology, compounds that modulate AQP3 activity are being explored for their ability to improve skin hydration and barrier function. In cancer research, inhibiting AQP3 expression or activity has shown potential in impeding tumor growth and metastasis.
AQP3 has been investigated as a potential therapeutic target in various contexts. For example, in dermatology, compounds that modulate AQP3 activity are being explored for their ability to improve skin hydration and barrier function. In cancer research, inhibiting AQP3 expression or activity has shown potential in impeding tumor growth and metastasis.
Yes, alterations in AQP3 function or expression can impact skin hydration. Decreased AQP3 activity has been associated with impaired water transport across skin cells, leading to decreased skin hydration and potentially contributing to dry skin conditions.
Yes, alterations in AQP3 function or expression can impact skin hydration. Decreased AQP3 activity has been associated with impaired water transport across skin cells, leading to decreased skin hydration and potentially contributing to dry skin conditions.
Currently, there are no specific targeted treatments available for AQP3-related disorders. However, management of symptoms and complications associated with these conditions may involve moisturizers, topical medications, and other dermatological interventions to help alleviate skin-related issues.
No, AQP3 is not exclusive to humans. It is found in various animal species, including mammals, birds, and reptiles. Its presence in different organisms suggests its evolutionary significance in water balance regulation and other biological processes.
The expression and activity of AQP3 can be regulated by various factors. Hormones, such as glucocorticoids and thyroid hormones, have been shown to influence AQP3 expression in certain tissues. Additionally, signaling pathways like the cAMP-protein kinase A pathway and the MAPK pathway have been implicated in the regulation of AQP3 activity.
The expression and activity of AQP3 can be regulated by various factors. Hormones, such as glucocorticoids and thyroid hormones, have been shown to influence AQP3 expression in certain tissues. Additionally, signaling pathways like the cAMP-protein kinase A pathway and the MAPK pathway have been implicated in the regulation of AQP3 activity.
Several compounds have been identified as potential AQP3 inhibitors or activators. For example, some natural substances like flavonoids and polyphenols have been found to inhibit AQP3 function. Conversely, certain synthetic compounds, such as AQP3 activators 4-Chlorobenzoylisothiocyanate and phloretin, have been shown to enhance AQP3 activity.
Several compounds have been identified as potential AQP3 inhibitors or activators. For example, some natural substances like flavonoids and polyphenols have been found to inhibit AQP3 function. Conversely, certain synthetic compounds, such as AQP3 activators 4-Chlorobenzoylisothiocyanate and phloretin, have been shown to enhance AQP3 activity.
Yes, AQP3 can interact with other proteins within the cell. For instance, it has been shown to interact with ezrin, a cytoskeletal protein, in the kidney. This interaction may play a role in the intracellular trafficking of AQP3 and its localization to specific membrane domains.
Yes, AQP3 can interact with other proteins within the cell. For instance, it has been shown to interact with ezrin, a cytoskeletal protein, in the kidney. This interaction may play a role in the intracellular trafficking of AQP3 and its localization to specific membrane domains.
AQP3 has been explored for drug delivery applications. Due to its water transport function, it can potentially be utilized to improve the delivery of hydrophilic drugs. By understanding the mechanisms of AQP3-mediated water transport, researchers are exploring ways to engineer drug carriers that can exploit these channels for efficient drug delivery.
AQP3 has been explored for drug delivery applications. Due to its water transport function, it can potentially be utilized to improve the delivery of hydrophilic drugs. By understanding the mechanisms of AQP3-mediated water transport, researchers are exploring ways to engineer drug carriers that can exploit these channels for efficient drug delivery.
Customer Reviews (8)
Write a reviewThis level of support saves researchers time and resources, enabling them to focus on the scientific aspects of their work and accelerate the overall progress of their studies.
its high quality and purity ensure accurate and reliable results.
If researchers require specific variants or modifications of AR protein, the manufacturer can work with them to provide customized products tailored to their needs.
Manufacturers may offer the option for custom protein production.
The AQP3 protein exhibits several valuable attributes that make it an excellent choice for my trials.
With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.
the stability of the AQP3 protein enables me to conduct experiments over an extended period, reducing the need for frequent restocking and promoting experimental consistency.
Their expertise can help troubleshoot problems, suggest alternative approaches, or provide recommendations for optimizing experimental protocols.
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