Recombinant Full Length Human ARHGAP25 Protein, GST-tagged

• Cat.No.: ARHGAP25-1094HF
• Product Overview: Human ARHGAP25 full-length ORF ( AAH39591.1, 1 a.a. - 458 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ARHGAPs, such as ARHGAP25, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 78.2 kDa
• Protein Length: 458 amino acids
• AA Sequence: MSLGQSACLF LSIARSRSVM TGEQMAAFHP SSTPNPLERP IKMGWLKKQR SIVKNWQQRY FVLRAQQLYY YKDEEDTKPQ GCMYLPGCTI KEIATNPEEA GKFVFEIIPA SWDQNRMGQD SYVLMASSQA EMEEWVKFLR RVAGTPCGAV FGQRLDETVA YEQKFGPHLV PILVEKCAEF ILEHGRNEEG IFRLPGQDNL VKQLRDAFDA GERPSFDRDT DVHTVASLLK LYLRDLPEPV VPWSQYEGFL LCGQLTNADE AKAQQELMKQ LSILPRDNYS LLSYICRFLH EIQLNCAVNK MSVDNLATVI GVNLIRSKVE DPAVIMRGTP QIQRVMTMMI RDHEVLFPKS KDIPLSPPAQ KNDPKKAPVA RSSVGWDATE DLRISRTDSF SSMVRCREPS CFHWVLPLVQ AIPCKACSRV AIWGVLGDAV AVGAAATDSS EHTLKAWPLS KSSFYWHL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARHGAP25 Rho GTPase activating protein 25 [ Homo sapiens ]
• Official Symbol: ARHGAP25
• Synonyms: ARHGAP25; Rho GTPase activating protein 25; rho GTPase-activating protein 25; KIAA0053; rho-type GTPase-activating protein 25; KAIA0053
• Gene ID: 9938
• mRNA Refseq: NM_001007231
• Protein Refseq: NP_001007232
• MIM: 610587
• UniProt ID: P42331

Reviews

08/18/2021

The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.

08/18/2021

In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

01/29/2021

Its purity and integrity have consistently delivered reliable and robust results in my research.

09/27/2019

Their prompt and knowledgeable guidance has been instrumental in effectively addressing my queries and optimizing the utilization of the ARHGAP25 protein in my studies.

03/15/2019

Manufacturers should ensure the consistency and quality of ARHGAP25 protein products.

10/26/2018

The ARHGAP25 protein comes highly recommended for its outstanding performance in various experimental applications.

08/27/2017

Its purity, stability, and functionality make it an ideal choice for my research endeavors.

09/17/2016

The ARHGAP25 protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

Q&As

Are there any drugs or compounds known to specifically target ARHGAP25?

No drugs or compounds specifically targeting ARHGAP25 have been developed or identified to date. Given its regulatory role in Rho GTPases, targeting these GTPases might indirectly affect ARHGAP25 function. However, further research is needed to explore specific agents targeting ARHGAP25 activity.

Can ARHGAP25 be used as a diagnostic or prognostic marker for any diseases?

Currently, there is no established diagnostic or prognostic utility of ARHGAP25 in diseases. However, future research might uncover its potential as a biomarker for specific conditions, once its role in diseases is better understood.

Are there any known interacting partners of ARHGAP25?

The specific interacting partners of ARHGAP25 are not well-characterized. However, it is expected to interact with components of Rho GTPase signaling pathways and proteins involved in cytoskeletal dynamics. Further studies are needed to identify and understand its interacting partners.

Have there been any functional studies conducted on ARHGAP25 knockout or overexpression models?

There is limited information available on functional studies specifically focusing on ARHGAP25 knockout or overexpression models. Future studies utilizing such models will provide valuable insights into the biological role and significance of ARHGAP25.

Is ARHGAP25 involved in cellular signaling pathways other than Rho GTPase signaling?

There is limited evidence suggesting potential involvement of ARHGAP25 in other cellular signaling pathways. Some studies have suggested interactions with proteins involved in calcium signaling and Wnt signaling, but further research is required to fully understand the extent of its involvement.

Is there any evidence of ARHGAP25 playing a role in cell migration or invasion?

ARHGAP25 is implicated in the regulation of Rho GTPases, which are known to play crucial roles in cell migration and invasion. Though direct evidence is limited, it is plausible that ARHGAP25 may contribute to these processes through its influence on Rho GTPase activity.

Does ARHGAP25 have any known genetic variations or mutations associated with diseases?

Limited information is available on genetic variations or mutations in the ARHGAP25 gene and their association with diseases. More research is needed to determine if any mutations in ARHGAP25 contribute to disease development.

Can mutations or dysregulation of ARHGAP25 lead to neurological disorders?

Currently, there is no evidence linking mutations or dysregulation of ARHGAP25 to specific neurological disorders. However, since Rho GTPase signaling pathways are involved in neural development and function, it is possible that ARHGAP25 may have implications in neurological disorders. Further research is needed for a better understanding.

Is there any evidence suggesting the involvement of ARHGAP25 in cancer?

Currently, there is no significant evidence linking ARHGAP25 to cancer. However, since Rho GTPase signaling pathways are implicated in cancer progression, it is possible that ARHGAP25 may play a role in cancer biology. Further investigation is required to confirm its involvement.

Is ARHGAP25 a potential target for therapeutic interventions?

The therapeutic potential of targeting ARHGAP25 is not well explored yet. However, as it regulates Rho GTPase signaling, which has implications in various diseases, targeting ARHGAP25 could be a possibility for therapeutic interventions in the future. Further research is needed to assess its therapeutic potential.

Are there any animal models available to study ARHGAP25?

At present, there are no specific animal models developed to study ARHGAP25. However, it is possible to use general knockout or overexpression models to investigate the functional consequences of manipulating ARHGAP25 expression.

What tissues or cell types express ARHGAP25?

ARHGAP25 is expressed in various tissues and cell types, including the brain, heart, liver, lung, and immune cells. Its expression pattern suggests that it may have a widespread role in many different cellular processes.