Recombinant Full Length Human ARID3C Protein, GST-tagged

• Cat.No.: ARID3C-1352HF
• Product Overview: Human ARID3C full-length ORF ( AAI48444.1, 1 a.a. - 412 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 71.72 kDa
• Protein Length: 412 amino acids
• AA Sequence: MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA EEEEDAEEDE EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY EEQFKQLYEL DADPKRKEFL DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL FRLVTAKGGL VEVINRKVWR EVTRGLSLPT TITSAAFTLR TQYMKYLYPY ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP PPRGAQDPAL GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE ERLDGPLNLA GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP PPSTGPPSSI LP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ARID3C AT rich interactive domain 3C (BRIGHT-like) [ Homo sapiens ]
• Official Symbol: ARID3C
• Synonyms: ARID3C; AT rich interactive domain 3C (BRIGHT-like); AT rich interactive domain 3C (BRIGHT like); AT-rich interactive domain-containing protein 3C; ARID domain-containing protein 3C
• Gene ID: 138715
• mRNA Refseq: NM_001017363
• Protein Refseq: NP_001017363
• UniProt ID: A6NKF2

Reviews

09/30/2022

This level of support ensures that researchers have a seamless experience, enabling them to focus on their research goals without worrying about logistical or technical concerns.

03/06/2022

With their assistance, I can confidently delve into the intricacies of ARID3C and make significant contributions to the field of ARID3C-related research.

06/27/2020

This high-quality protein serves as an invaluable tool in unraveling the intricate mechanisms governed by ARID3C, enabling me to gain deeper insights into its functions and implications.

05/25/2019

Its versatility in various biological applications, along with its compatibility with different techniques, strongly recommend it as a preferred reagent for researchers in the field.

02/28/2019

They consistently stay at the forefront of scientific advancements and customer feedback, allowing them to refine the ARID3C protein based on emerging research trends.

02/06/2018

ARID3C protein offers numerous advantages in trials, ranging from its stability and bioactivity to the manufacturer's commitment to customer support.

12/18/2017

researchers highly appreciate ARID3C protein for its excellent performance in ELISA assays and protein electron microscopy structure analysis.

07/10/2017

An outstanding aspect of the manufacturer of the ARID3C protein is their commitment to providing excellent technical support.

Q&As

Is ARID3C exclusively expressed in B cells?

While ARID3C is primarily known for its role in B-cell development and function, it has also been reported to be expressed in other cell types, including T cells, myeloid cells, and some non-immune cell types. The exact significance and function of ARID3C in these cell types are still being explored.

Has ARID3C been implicated in any specific diseases or disorders?

ARID3C has been implicated in various diseases and disorders, including B-cell lymphomas, autoimmune disorders, and some viral infections. Dysregulation of ARID3C expression or activity has been observed in certain types of B-cell lymphomas, suggesting a potential role in tumor development. Additionally, ARID3C has been shown to play a role in the pathogenesis of autoimmune disorders, as its expression is altered in these conditions. Studies have also demonstrated the involvement of ARID3C in viral infections, where it can affect the immune response to the virus.

Are there any known small molecule inhibitors or activators of ARID3C?

Currently, there are no known small molecule inhibitors or activators specifically targeting ARID3C. Research efforts are focused on elucidating the underlying mechanisms of ARID3C regulation and identifying potential therapeutic agents that can modulate its activity. Development of small molecule inhibitors or activators targeting ARID3C may hold promise as future therapeutic interventions, but further studies are required.

Can ARID3C be targeted for therapeutic interventions?

Modulating ARID3C activity holds potential for therapeutic interventions, particularly in diseases involving B-cell dysregulation. However, more research is needed to fully understand the complex regulatory networks involving ARID3C and to develop targeted approaches for its manipulation.

Is ARID3C associated with any diseases?

Studies have suggested that aberrant expression or dysfunction of ARID3C may be associated with certain types of cancers, including B-cell lymphomas. Further research is needed to fully understand the role of ARID3C in cancer development and progression.

What are the potential therapeutic implications of targeting ARID3C?

Targeting ARID3C could have therapeutic implications in diseases involving B-cell dysregulation, such as B-cell lymphomas or autoimmune disorders. By modulating ARID3C activity, it may be possible to influence B-cell development, antibody production, and immune response, potentially leading to novel treatment approaches.

Are there any known genetic variants or mutations in ARID3C?

Currently, no specific genetic variants or mutations in ARID3C have been widely reported in the literature. However, studies are ongoing to identify potential genetic variations and their association with disease susceptibility and progression.

Is ARID3C associated with any specific signaling pathways?

ARID3C has been reported to be associated with several signaling pathways. It can be activated by various cytokines, such as Interleukin-2 (IL-2) and Interleukin-7 (IL-7), which are important for B-cell development and function. Additionally, ARID3C has been found to interact with components of the Wnt signaling pathway, suggesting a potential role in regulating cell proliferation and differentiation. The exact mechanisms and significance of these associations are still being investigated.

Are there any known interacting proteins with ARID3C?

ARID3C can interact with a variety of proteins, including other transcription factors, co-regulators, chromatin remodeling complexes, and DNA repair proteins. The specific interacting partners may vary depending on the cellular context and the target genes being regulated.

What are the target genes regulated by ARID3C?

ARID3C is known to regulate the expression of genes involved in B-cell development and function. It can interact with other transcription factors, co-regulators, and chromatin remodeling complexes to modulate the expression of these genes.

What are the cellular processes influenced by ARID3C?

ARID3C is involved in several cellular processes, including cell proliferation, differentiation, apoptosis, and immune response. It plays a crucial role in B-cell development and antibody production by regulating the expression of genes involved in these processes.

Are there any known interactions or regulators of ARID3C?

ARID3C can interact with other transcription factors, such as PU.1 and OCT-2, to form complexes that regulate gene expression in B cells. It can also be regulated by post-translational modifications, such as phosphorylation, which can modulate its activity.