Recombinant Full Length Human ARR3 Protein, GST-tagged
Cat.No. : | ARR3-1243HF |
Product Overview : | Human ARR3 full-length ORF ( AAH12096, 1 a.a. - 359 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 65.01 kDa |
Protein Length : | 359 amino acids |
AA Sequence : | MSKVFKKTSS NGKLSIYLGK RDFVDHVDTV EPIDGVVLVD PEYFKCRKLF VMLTCAFRYG RDDLEVIGLT FRKDLYVQTL QVVPAESSSP QGPLTVLQER LLHKLGDNAY PFTLQMVTNL PCSVTLQPGP EDAGKPCGID FEVKSFCAEN PEETVSKRDY VRLVVRKVQF APPEAGPGPS AQTIRRFLLS AQPLQLQAWM DREVHYHGEP ISVNVSINNC TNKVIKKIKI SVDQITDVVL YSLDKYTKTV FIQEFTETVA ANSSFSQSFA VTPILAASCQ KRGLALDGKL KHEDTNLASS TIIRPGMDKE LLGILVSYKV RVNLMVSCGG ILGDLTASDV GVELPLVLIH PKPSYEAAR |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARR3 arrestin 3, retinal (X-arrestin) [ Homo sapiens ] |
Official Symbol : | ARR3 |
Synonyms : | ARR3; arrestin 3, retinal (X-arrestin); arrestin-C; arrestin 4; ARRX; cArr; C-arrestin; X-arrestin; cone arrestin; retinal cone arrestin-3 |
Gene ID : | 407 |
mRNA Refseq : | NM_004312 |
Protein Refseq : | NP_004303 |
MIM : | 301770 |
UniProt ID : | P36575 |
Products Types
◆ Recombinant Protein | ||
ARR3-854H | Recombinant Human ARR3 protein, GST-tagged | +Inquiry |
ARR3-3694C | Recombinant Chicken ARR3 | +Inquiry |
Arr3-3641R | Recombinant Rat Arr3, GST-tagged | +Inquiry |
◆ Lysates | ||
ARR3-129HCL | Recombinant Human ARR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionWhile ARR3 is primarily expressed in cone cells, studies have suggested that it may have additional roles in non-visual tissues. These include modulating GPCR signaling in other cell types, such as neurons and immune cells, and potentially contributing to cellular processes like synaptic transmission and immune response regulation.
There is ongoing research exploring the potential use of ARR3 as a biomarker for certain eye diseases. Changes in the expression or localization of ARR3 have been observed in conditions like age-related macular degeneration (AMD) and retinitis pigmentosa (RP), suggesting its potential as a diagnostic or prognostic indicator in these diseases.
ARR3 is a subtype of arrestin proteins that is specifically expressed in cone cells of the retina. It differs from other arrestin proteins, such as ARR1 (also known as arrestin-1), which is expressed in rod cells and plays a similar role in the desensitization of rod photoreceptors.
The expression and activity of ARR3 are tightly regulated to ensure proper visual function. Several factors, including light exposure, intracellular calcium levels, and protein kinases, can impact ARR3's localization, binding affinity, and activity, ultimately modulating its efficiency in desensitizing cone opsins.
Mutations or dysregulation of ARR3 have been linked to certain visual disorders, such as cone dystrophy and night blindness. These conditions are characterized by impaired cone cell function and visual impairment, underscoring the importance of ARR3 in maintaining normal cone cell physiology.
By binding to cone opsins, ARR3 helps to reset the signaling cascade after absorption of light, allowing the cones to respond to subsequent visual stimuli. This process is crucial for maintaining proper visual sensitivity and preventing adaptation or saturation of the photoreceptor cells.
Customer Reviews (3)
Write a reviewThe ARR3 protein is renowned for its exceptional quality and reliability, making it an ideal choice to fulfill my experimental requirements.
With the ARR3 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
With its high purity and stability, this protein ensures dependable and accurate results, which are crucial for the success of my research endeavors.
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