Recombinant Full Length Human ART3 Protein, GST-tagged

• Cat.No.: ART3-1018HF
• Product Overview: Human ART3 full-length ORF ( AAH08397, 27 a.a. - 389 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 65.67 kDa
• Protein Length: 389 amino acids
• AA Sequence: EVLDMADNAF DDEYLKCTDR MEIKYVPQLL KEEKASHQQL DTVWENAKAK WAARKTQIFL PMNFKDNHGI ALMAYISEAQ EQTPFYHLFS EAVKMAGQSR EDYIYGFQFK AFHFYLTRAL QLLRKPCEAS SKTVVYRTSQ GTSFTFGGLN QARFGHFTLA YSAKPQAAND QLTVLSIYTC LGVDIENFLD KESERITLIP LNEVFQVSQE GAGNNLILQS INKTCSHYEC AFLGGLKTEN CIENLEYFQP IYVYNPGEKN QKLEDHSEKN WKLEDHGEKN QKLEDHGVKI LEPTQIPGMK IPEPFPLPED KSQGNINNPT PGPVPVPGPK SHPSASLGKL LLPQFGMVII LISVSAINLF VAL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ART3 ADP-ribosyltransferase 3 [ Homo sapiens ]
• Official Symbol: ART3
• Synonyms: ART3; ADP-ribosyltransferase 3; ecto-ADP-ribosyltransferase 3; mono-ADP-ribosyltransferase; mono(ADP-ribosyl)transferase 3; NAD(P)(+)--arginine ADP-ribosyltransferase 3; FLJ26404
• Gene ID: 419
• mRNA Refseq: NM_001130016
• Protein Refseq: NP_001123488
• MIM: 603086
• UniProt ID: Q13508

Reviews

01/02/2023

The ART3 Protein boasts remarkable stability, ensuring its integrity is maintained during storage and experimentation.

08/18/2022

One remarkable aspect of the ART3 Protein is the outstanding technical support provided by the manufacturer.

06/29/2016

Equally noteworthy is the remarkable technical support provided by the manufacturer.

Q&As

What are some known substrates of ART3?

ART3 ADP-ribosylates specific arginine residues on target proteins, including CD28, a critical co-stimulatory molecule in T cell activation.

Are there any known diseases or disorders associated with mutations in the ART3 gene?

Mutations in the ART3 gene have not been directly linked to specific diseases or disorders in humans so far.

How is ART3 expression regulated in normal physiological conditions?

The precise regulation of ART3 gene expression is not well characterized, but it may be influenced by various cellular and immune signaling pathways.

Is the activity of ART3 influenced by any cofactors or regulators?

ART3 activity depends on the availability of NAD+ as a substrate and can also be influenced by various cellular signaling pathways related to immune responses.

Does ART3 activity change under pathological conditions?

Dysregulated ADP-ribosylation, including ART3 activity, has been implicated in various diseases. However, the specific role of ART3 in these conditions requires further investigation.

Are there any known animal models or experimental systems used to study ART3 functions?

Animal models, such as ART3 knockout mice, have been generated to investigate the role of ART3 in vivo, providing insights into its physiological functions.

How does ART3 catalyze ADP-ribosylation?

ART3 transfers ADP-ribose from NAD+ to specific target proteins, modifying their structure and function.