Recombinant Full Length Human ASB1 Protein, GST-tagged

• Cat.No.: ASB1-1295HF
• Product Overview: Human ASB1 full-length ORF ( AAH14528, 1 a.a. - 335 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 62.59 kDa
• Protein Length: 335 amino acids
• AA Sequence: MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL QTLRSLLQEE SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK GAEVDLVDVK GQTALYVAVV NGHLESTQIL LEAGADPNGS RHHRSTPVYH ASRVGRADIL KALIRYGADV DVNHHLTPDV QPRFSRRLTS LVVCPLYISA AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM DAVLRHGCEA AFVSLLVEFG ANLNLVKWES LGPESRGRRK VDPEALQVFK EARSVPRTLL CLCRVAVRRA LGKHRLHLIP SLPLPDPIKK FLLHE
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB1 ankyrin repeat and SOCS box containing 1 [ Homo sapiens ]
• Official Symbol: ASB1
• Synonyms: ASB-1
• Gene ID: 51665
• mRNA Refseq: NM_001040445.1
• Protein Refseq: NP_001035535.1
• MIM: 605758
• UniProt ID: Q9Y576

Reviews

03/05/2017

The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.

11/20/2016

Its unique properties make ASB1 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

09/13/2016

In addition to its scientific merits, the manufacturer of ASB1 protein stands out for its outstanding technical support.

Q&As

Can ASB1 regulate signal transduction pathways?

Yes, ASB1 has been shown to regulate various signal transduction pathways, including those involving growth factors, cytokines, and hormone receptors.

Are there any genetic variations in the ASB1 gene?

Genetic variations have been identified in the ASB1 gene, but their specific implications and associations with diseases or phenotypic traits are still under investigation.

How does ASB1 target proteins for degradation?

ASB1 has a SOCS box domain that recruits the necessary machinery to tag proteins with ubiquitin, marking them for degradation by the proteasome.

Can ASB1 interact with other proteins?

Yes, ASB1 can interact with different proteins through its ankyrin repeat domain, enabling its association with specific substrates for ubiquitination.

Is ASB1 involved in muscle development?

Yes, ASB1 has been implicated in muscle development and regeneration through its interaction with specific proteins involved in muscle differentiation.

Does ASB1 have any association with cancer?

ASB1 has been recognized as a potential tumor suppressor in certain cancers, as its downregulation can lead to dysregulation of cellular processes and contribute to tumor growth.

Does ASB1 have a role in neuronal functions?

ASB1 has been found to play a role in neuronal functions, including synaptic plasticity and regulation of neurotransmitter receptors.

Does ASB1 have any role in immune responses?

Yes, ASB1 has been reported to play a role in modulating immune responses by targeting specific proteins for ubiquitin-mediated degradation.