Recombinant Full Length Human ASB12 Protein, GST-tagged

• Cat.No.: ASB12-1374HF
• Product Overview: Human ASB12 full-length ORF (BAC04888.1, 1 a.a. - 318 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 61.4 kDa
• Protein Length: 318 amino acids
• AA Sequence: MRIVLQLAKM NLMDITKIFS LLQPDKEEED TDTEEKQALN QAVYDNDSYT LDQLLRQERY KRFINSRSGW GVPGTPLRLA ASYGHLSCLQ VLLAHGADVD SLDVKAQTPL FTAVSHGHLD CVRVLLEAGA SPGGSIYNNC SPVLTAARDG AVAILQEPLD HGAEANVKAK LPVWASNIAS CSGPLYLAAV YGHLDCFRLL LLHGADPDYN CTDQGLLARV PRPRTLLEIC LHHNCEPEYI QLLIDFGANI YLPSLSLDLT SQDDKGIALL LQARATPRSL LSQVRLVVRR ALCQAGQPQA INQLDIPPML ISYLKHQL
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB12 ankyrin repeat and SOCS box containing 12 [ Homo sapiens (human) ]
• Official Symbol: ASB12
• Synonyms: ASB12; ankyrin repeat and SOCS box containing 12; ankyrin repeat and SOCS box protein 12; ankyrin repeat domain-containing SOCS box protein Asb-12
• Gene ID: 142689
• mRNA Refseq: NM_130388
• Protein Refseq: NP_569059
• MIM: 300891
• UniProt ID: Q8WXK4

Reviews

01/16/2018

Its usage in ELISA and protein electron microscopy structure analysis has been reported to yield highly reproducible and interpretable results, providing valuable insights into the molecular mechanisms and biological processes under investigation.

01/06/2017

The ASB12 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis.

03/31/2016

researchers highly recommend the ASB12 protein due to its excellent performance in ELISA and its suitability for protein electron microscopy structure analysis.

Q&As

Can ASB12 regulate protein turnover and stability?

Yes, ASB12 is believed to regulate protein turnover and stability by targeting proteins for degradation through the ubiquitin-proteasome system.

Can ASB12 influence cell growth and proliferation?

ASB12's association with protein degradation pathways implies its potential role in regulating cell growth and proliferation, although precise mechanisms are still being investigated.

Does ASB12 interact with other proteins?

Yes, ASB12 can interact with different protein substrates, facilitating their ubiquitination and subsequent degradation via the ubiquitin-proteasome system.

Is ASB12 involved in cellular signaling pathways?

ASB12's SOCS box domain suggests its possible involvement in modulating cellular signaling by targeting specific proteins for degradation.

Does ASB12 have a role in neural development?

The involvement of ASB12 in neural development is not extensively studied, and further research is needed to determine if it plays a role in this process.

Can ASB12 impact fertility or reproductive processes?

ASB12's expression in certain tissues like the placenta suggests its potential involvement in fertility or reproductive processes, although further investigations are needed for a comprehensive understanding.

Does ASB12 have RNA-binding properties?

ASB12 does not have known RNA-binding domains or motifs, and its functions primarily revolve around protein degradation mechanisms.