Recombinant Full Length Human ASB15 Protein, GST-tagged

• Cat.No.: ASB15-1373HF
• Product Overview: Human ASB15 full-length ORF ( AAI66689.1, 1 a.a. - 588 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 64.7 kDa
• Protein Length: 588 amino acids
• AA Sequence: MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK AGLVENVRTL LEKGVWPNTK NDKGETPLLI AVKKGSYDMV STLIKHNTSL DQPCVKRWSA MHEAAKQGRK DIVALLLKHG GNVHLRDGFG VTPLGVAAEY GHCDVLEHLI HKGGDVLALA DDGASVLFEA AGGGNPDCIS LLLEYGGSGN VPNRAGHLPI HRAAYEGHYL ALKYLIPVTS KNAIRKSGLT PIHSAADGQN AQCLELLIEN GFDVNTLLAD HISQSYDDER KTALYFGVSN NDVHCTEVLL AAGADPNLDP LNCLLVAVRA NNYEIVRLLL SHGANVNCYF MHVNDTRFPS VIQYALNDEV MLRLLLNNGY QVEMCFDCMH GDIFGNSFVW SEIQEEVLPG WTSCVIKDNP FCEFITVPWM KHLVGRVTRV LIDYMDYVPL CAKLKSALEV QREWPEIRQI LENPCSLKHL CRLKIRRLMG LQKLCQPASV EKLPLPPAIQ RYILFKEYDL YGQELKLT
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB15 ankyrin repeat and SOCS box containing 15 [ Homo sapiens ]
• Official Symbol: ASB15
• Synonyms: ASB15; ankyrin repeat and SOCS box containing 15; ankyrin repeat and SOCS box protein 15; FLJ43370; ASB-15; ankyrin repeat and SOCS box-containing 15; DKFZp779M1258
• Gene ID: 142685
• mRNA Refseq: NM_080928
• Protein Refseq: NP_563616
• MIM: 619757
• UniProt ID: Q8WXK1

Reviews

08/26/2021

It has been shown to play a crucial role in multiple cellular processes, making it highly valuable for investigations into cell signaling, inflammation, and immune responses.

06/22/2021

With the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.

11/09/2020

Incorporating the ASB15 protein into your research will not only meet but exceed your expectations, enabling you to advance your scientific discoveries with confidence.

Q&As

How is ASB15 protein linked to Parkinson's disease?

Research suggests that ASB15 protein may influence the degradation of alpha-synuclein, a protein that forms clumps in the brains of Parkinson's disease patients.

Can ASB15 protein be used as a biomarker for Parkinson's disease?

It is unclear whether ASB15 protein can serve as a reliable biomarker for Parkinson's disease, as further research is needed to determine its diagnostic potential.

Are there any treatment options specifically targeting ASB15 protein?

Currently, there are no specific treatments available that directly target ASB15 protein. Treatment for Parkinson's disease mainly focuses on managing symptoms and slowing disease progression.

Can ASB15 protein dysfunction cause Parkinson's disease?

While genetic variations in the ASB15 gene are associated with an increased risk of Parkinson's disease, it is important to note that Parkinson's disease is a complex condition with multiple contributing factors, and ASB15 dysfunction alone may not be sufficient to cause the disease.

Are there any disorders associated with ASB15 protein dysfunction?

Recent studies have linked genetic variations in the ASB15 gene to an increased risk of developing Parkinson's disease, a progressive neurodegenerative disorder.

Is ASB15 protein involved in any other neurological disorders?

To date, the association between ASB15 protein and Parkinson's disease is the most well-established link, though further research is needed to explore its potential involvement in other neurological disorders.

How is ASB15 protein dysfunction investigated in relation to Parkinson's disease?

Studies typically involve genetic analyses of large populations to identify common genetic variants in the ASB15 gene that are associated with an increased risk of Parkinson's disease.