Recombinant Full Length Human ASB3 Protein, GST-tagged
Cat.No. : | ASB3-1272HF |
Product Overview : | Human ASB3 full-length ORF ( AAH06488.1, 1 a.a. - 518 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2011] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 82.72 kDa |
Protein Length : | 518 amino acids |
AA Sequence : | MDFTEAYADT CSTVGLAARE GNVKVLRKLL KKGRSVDVAD NRGWMPIHEA AYHNSVECLQ MLINADSSEN YIKMKTFEGF CALHLAASQG HWKIVQILLE AGADPNATTL EETTPLFLAV ENGQIDVLRL LLQHGANVNG SHSMCGWNSL HQASFQENAE IIKLLLRKGA NKECQDDFGI TPLFVAAQYG KLESLSILIS SGANVNCQAL DKATPLFIAA QEGHTKCVEL LLSSGADPDL YCNEDSWQLP IHAAAQMGHT KILDLLIPLT NRACDTGLNK VSPVYSAVFG GHEDCLEILL RNGYSPDAQA CLVFGFSSPV CMAFQKDCEF FGIVNILLKY GAQINELHLA YCLKYEKFSI FRYFLRKGCS LGPWNHIYEF VNHAIKAQAK YKEWLPHLLV AGFDPLILLC NSWIDSVSID TPIFTLEFTN WKTLAPAVER MLSARASNAW ILQQHIATVP SLTHLCRLEI RSSLKSERLR SDSYISQLPL PRSLHNYLLY EDVLRMYEVP ELAAIQDG |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ASB3 ankyrin repeat and SOCS box containing 3 [ Homo sapiens ] |
Official Symbol : | ASB3 |
Synonyms : | ASB3; ankyrin repeat and SOCS box containing 3; ankyrin repeat and SOCS box protein 3; ASB 3; ASB-3 |
Gene ID : | 51130 |
mRNA Refseq : | NM_001201965 |
Protein Refseq : | NP_001188894 |
MIM : | 605760 |
UniProt ID : | Q9Y575 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, ASB3 has been shown to interact with several proteins, including Cullin 5, Elongin BC complex, and the E3 ubiquitin ligase complex, among others.
ASB3 has been reported to target proteins such as Notch1, Smurf1, and Fanconi anemia-associated protein FANCC for ubiquitination and subsequent degradation.
ASB3 is involved in regulating various pathways, including the Notch signaling pathway, TGF-β signaling pathway, and Wnt/β-catenin signaling pathway, among others.
Currently, there are no known small molecules or drugs specifically targeting ASB3 activity, but further research may unveil potential therapeutic interventions.
Yes, various genetic variations and polymorphisms in the ASB3 gene have been identified, some of which have been associated with certain diseases and conditions.
Mutations in the ASB3 gene have been found in individuals with intellectual disability and developmental delay, suggesting a potential role in these disorders.
The regulation of ASB3 expression by environmental factors is not well-documented. More research is needed to investigate this aspect.
Customer Reviews (3)
Write a reviewIts versatility and reliability make it a great asset in the pursuit of scientific discoveries.
With the ASB3 protein, researchers can confidently delve into the complexity of protein structures and gain deeper insights into their functions.
Its exceptional properties and reliable results make it a valuable tool in various experimental applications.
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