Recombinant Full Length Human ASCL1 Protein, C-Flag-tagged
Cat.No. : | ASCL1-754HFL |
Product Overview : | Recombinant Full Length Human ASCL1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 25.3 kDa |
AA Sequence : | MESSAKMESGGAGQQPQPQPQQPFL PPAACFFATAAAAAAAAAAAAAQSA QQQQQQQQQQQQAPQLRPAA DGQPSGGGHKSAPKQVKRQRSSSPE LMRCKRRLNFSGFGYSLPQQQPAAV ARRNERERNRVKLVNLGFAT LREHVPNGAANKKMSKVETLRSAVE YIRALQQLLDEHDAVSAAFQAGVLS PTISPNYSNDLNSMAGSPVS SYSSDEGSYDPLSPEEQELLDFTNW FTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transcription Factors |
Gene Name : | ASCL1 achaete-scute family bHLH transcription factor 1 [ Homo sapiens (human) ] |
Official Symbol : | ASCL1 |
Synonyms : | ASH1; HASH1; MASH1; bHLHa46 |
Gene ID : | 429 |
mRNA Refseq : | NM_004316.4 |
Protein Refseq : | NP_004307.2 |
MIM : | 100790 |
UniProt ID : | P50553 |
Products Types
◆ Recombinant Protein | ||
ASCL1-784M | Recombinant Mouse ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ASCL1-474R | Recombinant Rat ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ASCL1-386H | Recombinant Human ASCL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ascl1-1739M | Recombinant Mouse Ascl1 Protein, Myc/DDK-tagged | +Inquiry |
ASCL1-901H | Recombinant Human ASCL1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ASCL1-8654HCL | Recombinant Human ASCL1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (8)
Ask a questionYes, ASCL1 is associated with several human diseases, including neuroblastoma and small cell lung cancer, where it is often overexpressed and contributes to tumor development.
Yes, ASCL1 is a key regulator of neurogenesis. It acts as a transcription factor that directs the differentiation of neural stem cells into neurons during development.
Yes, ASCL1, in combination with other transcription factors, can induce the reprogramming of somatic cells into neurons in vitro, demonstrating its ability to change cell fate.
Yes, ASCL1 is critical for the formation of several neuronal subtypes, including subtypes in the cerebral cortex, olfactory bulb, and autonomic ganglia.
Although ASCL1 is primarily associated with neural development, it is also expressed in specific regions of the developing lung, where it influences lung neuroendocrine cell differentiation.
ASCL1 is actively being researched as a potential therapeutic target in neuroblastoma and small cell lung cancer. Developing drugs that inhibit ASCL1 may help treat these diseases.
While ASCL1's role in adult neurogenesis is not fully understood, studies suggest that it may play a role in the generation of newborn neurons in certain brain regions, such as the olfactory bulb.
ASCL1 interacts with various proteins involved in neural development and transcriptional regulation, including NEUROD1, TCF3, TLE1, and HDAC1.
Customer Reviews (3)
Write a reviewTheir collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.
the manufacturer's support is crucial for researchers using ASCL1 protein in trials.
They may offer educational resources such as technical guides, protocols, and application notes, which can aid researchers in understanding the principles, techniques, and potential applications of ASCL1 protein in their studies.
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