Recombinant Full Length Human ASCL3 Protein, GST-tagged
Cat.No. : | ASCL3-1249HF |
Product Overview : | Human ASCL3 full-length ORF ( NP_065697.1, 1 a.a. - 181 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 47.3 kDa |
Protein Length : | 181 amino acids |
AA Sequence : | MMDNRGNSSL PDKLPIFPDS ARLPLTRSFY LEPMVTFHVH PEAPVSSPYS EELPRLPFPS DSLILGNYSE PCPFSFPMPY PNYRGCEYSY GPAFTRKRNE RERQRVKCVN EGYAQLRHHL PEEYLEKRLS KVETLRAAIK YINYLQSLLY PDKAETKNNP GKVSSMIATT SHHADPMFRI V |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ASCL3 achaete-scute complex homolog 3 (Drosophila) [ Homo sapiens ] |
Official Symbol : | ASCL3 |
Synonyms : | ASCL3; achaete-scute complex homolog 3 (Drosophila); achaete scute complex (Drosophila) homolog like 3; achaete-scute homolog 3; bHLHa42; HASH3; Sgn1; ASH-3; bHLH transcriptional regulator Sgn-1; class A basic helix-loop-helix protein 42; bHLH transcription factor Sgn-1 (Salivary Glands 1); SGN1 |
Gene ID : | 56676 |
mRNA Refseq : | NM_020646 |
Protein Refseq : | NP_065697 |
MIM : | 609154 |
UniProt ID : | Q9NQ33 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, ASCL3 has been shown to play a role in embryonic development, particularly in the formation of the gastrointestinal tract.
ASCL3 expression and its dysregulation have been proposed as potential diagnostic markers for certain gastrointestinal diseases. However, further research is needed to establish its clinical utility.
ASCL3 acts as a transcription factor, binding to specific DNA sequences in the genome and regulating the expression of target genes involved in cellular differentiation and development.
Mutations or dysregulation of ASCL3 can lead to various gastrointestinal diseases, including colorectal cancer and inflammatory bowel diseases.
Yes, ASCL3 can interact with several other proteins to regulate its activity and downstream signaling pathways. Some known interacting proteins include β-catenin, SMAD4, and p300.
Customer Reviews (3)
Write a reviewChoosing the ASCL3 protein from this manufacturer not only provides me with a superior product but also grants me access to unparalleled technical support.
The manufacturer's extensive experience and expertise in the field of ASCL3 protein research make them a trusted partner.
The manufacturer's commitment to customer satisfaction and their willingness to customize solutions based on specific experimental requirements is commendable.
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