Recombinant Full Length Human ATP2A1 Protein, GST-tagged
Cat.No. : | ATP2A1-1244HF |
Product Overview : | Human ATP2A1 full-length ORF ( NP_004311.1, 1 a.a. - 994 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 135.7 kDa |
Protein Length : | 994 amino acids |
AA Sequence : | MEAAHAKTTE ECLAYFGVSE TTGLTPDQVK RNLEKYGLNE LPAEEGKTLW ELVIEQFEDL LVRILLLAAC ISFVLAWFEE GEETITAFVE PFVILLILIA NAIVGVWQER NAENAIEALK EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILAIKS TTLRVDQSIL TGESVSVIKH TEPVPDPRAV NQDKKNMLFS GTNIAAGKAL GIVATTGVGT EIGKIRDQMA ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ MSVCKMFIID KVDGDICLLN EFSITGSTYA PEGEVLKNDK PVRPGQYDGL VELATICALC NDSSLDFNEA KGVYEKVGEA TETALTTLVE KMNVFNTDVR SLSKVERANA CNSVIRQLMK KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP VKEKIMAVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SARFLEYETD LTFVGVVGML DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFGENEEVAD RAYTGREFDD LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI GGYVGAATVG AAAWWFLYAE DGPHVNYSQL THFMQCTEDN THFEGIDCEV FEAPEPMTMA LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR ALDLTQWLMV LKISLPVIGL DEILKFVARN YLEG |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 [ Homo sapiens ] |
Official Symbol : | ATP2A1 |
Synonyms : | ATP2A1; ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; ATP2A; sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; calcium pump 1; SR Ca(2+)-ATPase 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform |
Gene ID : | 487 |
mRNA Refseq : | NM_004320 |
Protein Refseq : | NP_004311 |
MIM : | 108730 |
UniProt ID : | O14983 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionYes, the expression and function of ATP2A1 recombinant protein in cardiomyocytes are regulated by different regulatory mechanisms, such as endogenous hormones and signaling pathways.
The recombinant ATP2A1 protein interacts with other proteins of the sarcoplasmic reticulum, such as calsequestrin and phospholamban, to regulate muscle contraction.
The ATP2A1 recombinant protein can be used as a drug target because it plays an important role in regulating muscle and cardiomyocyte function. However, there are no clinically applicable drugs targeting ATP2A1.
Impairment of the normal function of ATP2A1 recombinant protein in cardiomyocytes may contribute to the development of cardiovascular diseases, such as reduced myocardial contractility and heart failure.
Mutations in the ATP2A1 recombinant protein may cause calcium leakage and abnormal muscle contraction, leading to muscle diseases.
Certain drugs can affect the function of the recombinant ATP2A1 protein, such as calcium antagonists and cardiac agonists. These drugs regulate calcium homeostasis in muscle and cardiomyocytes.
Customer Reviews (3)
Write a reviewIt is noteworthy that the results of multiple experiments were highly consistent and reproducible.
The catalytic activity of ATP2A1 is very excellent, not only the catalytic effect is remarkable, but also has high selectivity, and its performance is impressive.
They produced ATP2A1 with high purity and accurate experimental results.
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