Recombinant Full Length Human AURKC Protein, GST-tagged
Cat.No. : | AURKC-1060HF |
Product Overview : | Human AURKC full-length ORF ( NP_001015878.1, 1 a.a. - 309 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 62 kDa |
Protein Length : | 309 amino acids |
AA Sequence : | MSSPRAVVQL GKAQPAGEEL ATANQTAQQP SSPAMRRLTV DDFEIGRPLG KGKFGNVYLA RLKESHFIVA LKVLFKSQIE KEGLEHQLRR EIEIQAHLQH PNILRLYNYF HDARRVYLIL EYAPRGELYK ELQKSEKLDE QRTATIIEEL ADALTYCHDK KVIHRDIKPE NLLLGFRGEV KIADFGWSVH TPSLRRKTMC GTLDYLPPEM IEGRTYDEKV DLWCIGVLCY ELLVGYPPFE SASHSETYRR ILKVDVRFPL SMPLGARDLI SRLLRYQPLE RLPLAQILKH PWVQAHSRRV LPPCAQMAS |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AURKC aurora kinase C [ Homo sapiens ] |
Official Symbol : | AURKC |
Synonyms : | AURKC; aurora kinase C; serine/threonine kinase 13 (aurora/IPL1 like) , STK13; ARK3; AurC; ARK-3; aurora 3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase 13; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like); AIE2; AIK3; SPGF5; STK13; aurora-C |
Gene ID : | 6795 |
mRNA Refseq : | NM_001015878 |
Protein Refseq : | NP_001015878 |
MIM : | 603495 |
UniProt ID : | Q9UQB9 |
Products Types
◆ Recombinant Protein | ||
AURKC-1115H | Recombinant Human AURKC Protein (S2-S309), GST tagged | +Inquiry |
Aurkc-532R | Recombinant Rat Aurkc Protein, His-tagged | +Inquiry |
Aurkc-531M | Recombinant Mouse Aurkc Protein, His-tagged | +Inquiry |
AURKC-1114H | Recombinant Human AURKC Protein (S2-S309), Tag Free | +Inquiry |
AURKC-530H | Recombinant Human AURKC Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AURKC-8559HCL | Recombinant Human AURKC 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionAURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.
The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.
It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.
The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.
AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.
Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.
Customer Reviews (3)
Write a reviewIt is very stable and can be stored and used for a long time.
This price is very reasonable and good value for money.
The activity is very strong and can meet my research needs.
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