| Description : |
The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
93.2 kDa |
| AA Sequence : |
MNHLNVLAKALYDNVAESPDELSFR KGDIMTVLEQDTQGLDGWWLCSLHG RQGIVPGNRLKILVGMYDKK PAGPGSGPPATPAQPQPGLHAPAPP ASQYTPMLPNTYQPQPDSVYLVPTP SKAQQGLYQVPGPSPQFQSP PAKQTSTFSKQTPHHPFPNPATDLY QVPPGPGGPAQDIYQVPPSAGMGHD IYQVPPSMDTRSWEGTKPPA KVVVPTRVGQGYVYEAAQPEQDEYD IPRHLLAPGPQDIYDVPPVRGLLPS QYGQEVYDTPPMAVKGPNGR DPLLEVYDVPPSVEKGLPPSNHHAV YDVPPSVSKDVPDGPLLREETYDVP PAFAKAKPFDPARTPLVLAA PPPDSPPAEDVYDVPPPAPDLYDVP PGLRRPGPGTLYDVPRERVLPPEVA DGGVVDSGVYAVPPPAEREA PAEGKRLSASSTGSTRSSQSASSLE VAGPGREPLELEVAVEALARLQQGV SATVAHLLDLAGSAGATGSW RSPSEPQEPLVQDLQAAVAAVQSAV HELLEFARSAVGNAAHTSDRALHAK LSRQLQKMEDVHQTLVAHGQ ALDAGRGGSGATLEDLDRLVACSRA VPEDAKQLASFLHGNASLLFRRTKA TAPGPEGGGTLHPNPTDKTS SIQSRPLPSPPKFTSQDSPDGQYEN SEGGWMEDYDYVHLQGKEEFEKTQK ELLEKGSITRQGKSQLELQQ LKQFERLEQEVSRPIDHDLANWTPA QPLAPGRTGGLGPSDRQLLLFYLEQ CEANLTTLTNAVDAFFTAVA TNQPPKIFVAHSKFVILSAHKLVFI GDTLSRQAKAADVRSQVTHYSNLLC DLLRGIVATTKAAALQYPSP
SAAQDMVERVKELGHSTQQFRRVLG QLAAATRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome |
| Protein Pathways : |
Chemokine signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Regulation of actin cytoskeleton |
