Recombinant Full Length Human BCL6 Protein, C-Flag-tagged

• Cat.No.: BCL6-305HFL
• Product Overview: Recombinant Full Length Human BCL6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 78.7 kDa
• AA Sequence: MASPADSCIQFTRHASDVLLNLNRL RSRDILTDVVIVVSREQFRAHKTVL MACSGLFYSIFTDQLKCNLS VINLDPEINPEGFCILLDFMYTSRL NLREGNIMAVMATAMYLQMEHVVDT CRKFIKASEAEMVSAIKPPR EEFLNSRMLMPQDIMAYRGREVVEN NLPLRSAPGCESRAFAPSLYSGLST PPASYSMYSHLPVSSLLFSD EEFRDVRMPVANPFPKERALPCDSA RPVPGEYSRPTLEVSPNVCHSNIYS PKETIPEEARSDMHYSVAEG LKPAAPSARNAPYFPCDKASKEEER PSSEDEIALHFEPPNAPLNRKGLVS PQSPQKSDCQPNSPTESCSS KNACILQASGSPPAKSPTDPKACNW KKYKFIVLNSLNQNAKPEGPEQAEL GRLSPRAYTAPPACQPPMEP ENLDLQSPTKLSASGEDSTIPQASR LNNIVNRSMTGSPRSSSESHSPLYM HPPKCTSCGSQSPQHAEMCL HTAGPTFPEEMGETQSEYSDSSCEN GAFFCNECDCRFSEEASLKRHTLQT HSDKPYKCDRCQASFRYKGN LASHKTVHTGEKPYRCNICGAQFNR PANLKTHTRIHSGEKPYKCETCGAR FVQVAHLRAHVLIHTGEKPY PCEICGTRFRHLQTLKSHLRIHTGE KPYHCEKCNLHFRHKSQLRLHLRQK HGAITNTKVQYRVSATDLPP
  ELPKACTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors

Gene Information

• Gene Name: BCL6 BCL6 transcription repressor [ Homo sapiens (human) ]
• Official Symbol: BCL6
• Synonyms: BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
• Gene ID: 604
• mRNA Refseq: NM_001706.5
• Protein Refseq: NP_001697.2
• MIM: 109565
• UniProt ID: P41182