Recombinant Full Length Human BIRC7 Protein, C-Flag-tagged

• Cat.No.: BIRC7-2176HFL
• Product Overview: Recombinant Full Length Human BIRC7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 32.6 kDa
• AA Sequence: MGPKDSAKCLHRGPQPSHWAAGDGP TQERCGPRSLGSPVLGLDTCRAWDH VDGQILGQLRPLTEEEEEEG AGATLSRGPAFPGMGSEELRLASFY DWPLTAEVPPELLAAAGFFHTGHQD KVRCFFCYGGLQSWKRGDDP WTEHAKWFPSCQFLLRSKGRDFVHS VQETHSQLLGSWDPWEEPEDAAPVA PSVPASGYPELPTPRREVQS ESAQEPGGVSPAQAQRAWWVLEPPG ARDVEAQLRRLQEERTCKVCLDRAV SIVFVPCGHLVCAECAPGLQ LCPICRAPVRSRVRTFLS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome

Gene Information

• Gene Name: BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ]
• Official Symbol: BIRC7
• Synonyms: KIAP; LIVIN; MLIAP; RNF50; ML-IAP
• Gene ID: 79444
• mRNA Refseq: NM_139317.3
• Protein Refseq: NP_647478.1
• MIM: 605737
• UniProt ID: Q96CA5