Recombinant Full Length Human BTK Protein, C-Flag-tagged
Cat.No. : | BTK-985HFL |
Product Overview : | Recombinant Full Length Human BTK Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 76.1 kDa |
AA Sequence : | MAAVILESIFLKRSQQKKKTSPLNF KKRLFLLTVHKLSYYEYDFERGRRG SKKGSIDVEKITCVETVVPE KNPPPERQIPRRGEESSEMEQISII ERFPYPFQVVYDEGPLYVFSPTEEL RKRWIHQLKNVIRYNSDLVQ KYHPCFWIDGQYLCCSQTAKNAMGC QILENRNGSLKPGSSHRKTKKPLPP TPEEDQILKKPLPPEPAAAP VSTSELKKVVALYDYMPMNANDLQL RKGDEYFILEESNLPWWRARDKNGQ EGYIPSNYVTEAEDSIEMYE WYSKHMTRSQAEQLLKQEGKEGGFI VRDSSKAGKYTVSVFAKSTGDPQGV IRHYVVCSTPQSQYYLAEKH LFSTIPELINYHQHNSAGLISRLKY PVSQQNKNAPSTAGLGYGSWEIDPK DLTFLKELGTGQFGVVKYGK WRGQYDVAIKMIKEGSMSEDEFIEE AKVMMNLSHEKLVQLYGVCTKQRPI FIITEYMANGCLLNYLREMR HRFQTQQLLEMCKDVCEAMEYLESK QFLHRDLAARNCLVNDQGVVKVSDF GLSRYVLDDEYTSSVGSKFP VRWSPPEVLMYSKFSSKSDIWAFGV LMWEIYSLGKMPYERFTNSETAEHI AQGLRLYRPHLASEKVYTIM YSCWHEKADERPTFKILLSNILDVM DEESTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Protein Kinase |
Protein Pathways : | B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Primary immunodeficiency |
Gene Name : | BTK Bruton tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | BTK |
Synonyms : | AT; ATK; BPK; XLA; IMD1; AGMX1; IGHD3; PSCTK1 |
Gene ID : | 695 |
mRNA Refseq : | NM_000061.3 |
Protein Refseq : | NP_000052.1 |
MIM : | 300300 |
UniProt ID : | Q06187 |
Products Types
◆ Recombinant Protein | ||
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BTK-457H | Recombinant Human BTK Protein, His (Fc)-Avi-tagged | +Inquiry |
BTK-06H | Recombinant Human BTK (R562W) Mutant Protein, GST-tagged | +Inquiry |
BTK-092H | Recombinant Human BTK Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
BTK-001HCL | Recombinant Human BTK cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1569 | BTK Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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