Recombinant Full Length Human CBFA2T2 Protein, GST-tagged
Cat.No. : | CBFA2T2-2755HF |
Product Overview : | Human CBFA2T2 full-length ORF (AAH40344, 1 a.a. - 614 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 93.28 kDa |
Protein Length : | 614 amino acids |
AA Sequence : | MGFHHVGQARLELLTSGDLPALASQ RAGITVGPEKRVPAMPGSPVEVKIQ SRSSPPTMPPLPPINPGGPRPVSFT PTALSNGINHSPPTLNGAPSPPQRF SNGPASSTSSALTNQQLPATCGARQ LSKLKRFLTTLQQFGNDISPEIGEK VRTLVLALVNSTVTIEEFHCKLQEA TNFPLRPFVIPFLKANLPLLQRELL HCARAAKQTPSQYLAQHEHLLLNTS IASPADSSELLMEVHGNGKRPSPER REENSFDRDTIAPEPPAKRVCTISP APRHSPALTVPLMNPGGQFHPTPPP LQHYTLEDIATSHLYREPNKMLEHR EVRDRHHSLGLNGGYQDELVDHRLT EREWADEWKHLDHALNCIMEMVEKT RRSMAVLRRCQGSDREELNYWKRRY NENTELRKTGTELVSRQHSPGSADS LSNDSQREFNSRPGTGYVPVEFWKK TEEAVNKVKIQAMSEVQKAVAEAEQ KAFEVIATERARMEQTIADVKRQAA EDAFLVINEQEESTENCWNCGRKAS ETCSGCNIARYCGSFCQHKDWERHH RLCGQNLHGQSPHGQGRPLLPVGRG SSARSADCSVPSPALDKTSATTSRS STPASVTAIDTNGL |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 [ Homo sapiens ] |
Official Symbol : | CBFA2T2 |
Synonyms : | CBFA2T2; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; protein CBFA2T2; MTGR1; ZMYND3; MTG8-like protein; MTG8-related protein 1; ETO homolog on chromosome 20; ETO homologous on chromosome 20; myeloid translocation-related protein 1; myeloid translocation gene-related protein 1; EHT; p85; DKFZp313F2116; |
Gene ID : | 9139 |
mRNA Refseq : | NM_001032999 |
Protein Refseq : | NP_001028171 |
MIM : | 603672 |
UniProt ID : | O43439 |
Products Types
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CBFA2T2-0451H | Recombinant Human CBFA2T2 Protein, GST-Tagged | +Inquiry |
CBFA2T2-1881C | Recombinant Chicken CBFA2T2 | +Inquiry |
CBFA2T2-2776M | Recombinant Mouse CBFA2T2 Protein | +Inquiry |
◆ Lysates | ||
CBFA2T2-7817HCL | Recombinant Human CBFA2T2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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