Recombinant Full Length Human CD14 Protein, C-Flag-tagged

• Cat.No.: CD14-1211HFL
• Product Overview: Recombinant Full Length Human CD14 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 38 kDa
• AA Sequence: MERASCLLLLLLPLVHVSATTPEPC ELDDEDFRCVCNFSEPQPDWSEAFQ CVSAVEVEIHAGGLNLEPFL KRVDADADPRQYADTVKALRVRRLT VGAAQVPAQLLVGALRVLAYSRLKE LTLEDLKITGTMPPLPLEAT GLALSSLRLRNVSWATGRSWLAELQ QWLKPGLKVLSIAQAHSPAFSCEQV RAFPALTSLDLSDNPGLGER GLMAALCPHKFPAIQNLALRNTGME TPTGVCAALAAAGVQPHSLDLSHNS LRATVNPSAPRCMWSSALNS LNLSFAGLEQVPKGLPAKLRVLDLS CNRLNRAPQPDELPEVDNLTLDGNP FLVPGTALPHEGSMNSGVVP
  ACARSTLSVGVSGTLVLLQGARGFA TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Hematopoietic cell lineage, MAPK signaling pathway, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway

Gene Information

• Gene Name: CD14 CD14 molecule [ Homo sapiens (human) ]
• Official Symbol: CD14
• Synonyms: CD14 antigen; CD14 molecule; monocyte differentiation antigen CD14
• Gene ID: 929
• mRNA Refseq: NM_000591.4
• Protein Refseq: NP_000582.1
• MIM: 158120
• UniProt ID: P08571