Recombinant Full Length Human CD247 Protein, C-Flag-tagged

• Cat.No.: CD247-1291HFL
• Product Overview: Recombinant Full Length Human CD247 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 16.3 kDa
• AA Sequence: MKWKALFTAAILQAQLPITEAQSFG LLDPKLCYLLDGILFIYGVILTALF LRVKFSRSADAPAYQQGQNQ LYNELNLGRREEYDVLDKRRGRDPE MGGKPRRKNPQEGLYNELQKDKMAE AYSEIGMKGERRRGKGHDGL
  YQGLSTATKDTYDALHMQALPPRTR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway

Gene Information

• Gene Name: CD247 CD247 molecule [ Homo sapiens (human) ]
• Official Symbol: CD247
• Synonyms: T3Z; CD3H; CD3Q; CD3Z; TCRZ; IMD25; CD3ZETA; CD3-ZETA
• Gene ID: 919
• mRNA Refseq: NM_198053.3
• Protein Refseq: NP_932170.1
• MIM: 186780
• UniProt ID: P20963