Recombinant Full Length Human CD59 Protein, C-Flag-tagged
Cat.No. : | CD59-1539HFL |
Product Overview : | Recombinant Full Length Human CD59 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 11.6 kDa |
AA Sequence : | MGIQGGSVLFGLLLVLAVFCHSGHS LQCYNCPNPTADCKTAVNCSSDFDA CLITKAGLQVYNKCWKFEHCNFNDV TTRLRENELTYYCCKKDLCNFNEQL ENGGTSLSEKTVLLLVTPFLAAAWS LHP TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome |
Protein Pathways : | Complement and coagulation cascades, Hematopoietic cell lineage |
Gene Name : | CD59 CD59 molecule (CD59 blood group) [ Homo sapiens (human) ] |
Official Symbol : | CD59 |
Synonyms : | 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20 |
Gene ID : | 966 |
mRNA Refseq : | NM_000611.6 |
Protein Refseq : | NP_000602.1 |
MIM : | 107271 |
UniProt ID : | P13987 |
Products Types
◆ Recombinant Protein | ||
CD59-918R | Recombinant Rat CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD59-0836H | Recombinant Human CD59 Protein, GST-Tagged | +Inquiry |
CD59-3116H | Recombinant Human CD59 Protein, MYC/DDK-tagged | +Inquiry |
CD59-543H | Recombinant Human CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD59-572R | Recombinant Rhesus Macaque CD59 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CD59-1968HCL | Recombinant Human CD59 cell lysate | +Inquiry |
CD59-1365RCL | Recombinant Rat CD59 cell lysate | +Inquiry |
CD59-1019CCL | Recombinant Cynomolgus CD59 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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