| Description : |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
94.8 kDa |
| AA Sequence : |
MGPWSRSLSALLLLLQVSSWLCQEP EPCHPGFDAESYTFTVPRRHLERGR VLGRVNFEDCTGRQRTAYFS LDTRFKVGTDGVITVKRPLRFHNPQ IHFLVYAWDSTYRKFSTKVTLNTVG HHHRPPPHQASVSGIQAELL TFPNSSPGLRRQKRDWVIPPISCPE NEKGPFPKNLVQIKSNKDKEGKVFY SITGQGADTPPVGVFIIERE TGWLKVTEPLDRERIATYTLFSHAV SSNGNAVEDPMEILITVTDQNDNKP EFTQEVFKGSVMEGALPGTS VMEVTATDADDDVNTYNAAIAYTIL SQDPELPDKNMFTINRNTGVISVVT TGLDRESFPTYTLVVQAADL QGEGLSTTATAVITVTDTNDNPPIF NPTTYKGQVPENEANVVITTLKVTD ADAPNTPAWEAVYTILNDDG GQFVVTTNPVNNDGILKTAKGLDFE AKQQYILHVAVTNVVPFEVSLTTST ATVTVDVLDVNEAPIFVPPE KRVEVSEDFGVGQEITSYTAQEPDT FMEQKITYRIWRDTANWLEINPDTG AISTRAELDREDFEHVKNST YTALIIATDNGSPVATGTGTLLLIL SDVNDNAPIPEPRTIFFCERNPKPQ VINIIDADLPPNTSPFTAEL THGASANWTIQYNDPTQESIILKPK MALEVGDYKINLKLMDNQNKDQVTT LEVSVCDCEGAAGVCRKAQP VEAGLQIPAILGILGGILALLILIL LLLLFLRRRAVVKEPLLPPEDDTRD NVYYYDEEGGGEEDQDFDLS QLHRGLDARPEVTRNDVAPTLMSVP RYLPRPANPDEIGNFIDENLKAADT DPTAPPYDSLLVFDYEGSGS
EAASLSSLNSSESDKDQDYDYLNEW GNRFKKLADMYGGGEDDTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways : |
Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer |
