| Description : |
This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. |
| Source : |
In Vitro Cell Free System |
| Species : |
Human |
| Tag : |
GST |
| Form : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
| Molecular Mass : |
115.5 kDa |
| Protein Length : |
812 amino acids |
| AA Sequence : |
MEAFQELRKPSARLECDHCSFRGTD YENVQIHMGTIHPEFCDEMDAGGLG KMIFYQKSAKLFHCHKCFFTSKMYS NVYYHITSKHASPDKWNDKPKNQLN KETDPVKSPPLPEHQKIPCNSAEPK SIPALSMETQKLGSVLSPESPKPTP LTPLEPQKPGSVVSPELQTPLPSPE PSKPASVSSPEPPKSVPVCESQKLA PVPSPEPQKPAPVSPESVKATLSNP KPQKQSHFPETLGPPSASSPESPVL AASPEPWGPSPAASPESRKSARTTS PEPRKPSPSESPEPWKPFPAVSPEP RRPAPAVSPGSWKPGPPGSPRPWKS NPSASSGPWKPAKPAPSVSPGPWKP IPSVSPGPWKPTPSVSSASWKSSSV SPSSWKSPPASPESWKSGPPELRKT APTLSPEHWKAVPPVSPELRKPGPP LSPEIRSPAGSPELRKPSGSPDLWK LSPDQRKTSPASLDFPESQKSSRGG SPDLWKSSFFIEPQKPVFPETRKPG PSGPSESPKAASDIWKPVLSIDTEP RKPALFPEPAKTAPPASPEARKRAL FPEPRKHALFPELPKSALFSESQKA VELGDELQIDAIDDQKCDILVQEEL LASPKKLLEDTLFPSSKKLKKDNQE SSDAELSSSEYIKTDLDAMDIKGQE SSSDQEQVDVESIDFSKENKMDMTS PEQSRNVLQFTEEKEAFISEEEIAK YMKRGKGKYYCKICCCRAMKKGAVL HHLVNKHNVHSPYKCTICGKAFLLE SLLKNHVAAHGQSLLKCPRCNFESN FPRGFKKHLTHCQSRHNEEANKKLM EALEPPLEEQQI |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
