Recombinant Full Length Human CHRM1 Protein

• Cat.No.: CHRM1-3220HF
• Product Overview: Human CHRM1 full-length ORF (NP_000729.2) recombinant protein without tag.

Specification

• Description: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 51.4 kDa
• Protein Length: 458 amino acids
• AA Sequence: MNTSAPPAVSPNITVLAPGKGPWQV AFIGITTGLLSLATVTGNLLVLISF KVNTELKTVNNYFLLSLACADLIIG TFSMNLYTTYLLMGHWALGTLACDL WLALDYVASNASVMNLLLISFDRYF SVTRPLSYRAKRTPRRAALMIGLAW LVSFVLWAPAILFWQYLVGERTVLA GQCYIQFLSQPIITFGTAMAAFYLP VTVMCTLYWRIYRETENRARELAAL QGSETPGKGGGSSSSSERSQPGAEG SPETPPGRCCRCCRAPRLLQAYSWK EEEEEDEGSMESLTSSEGEEPGSEV VIKMPMVDPEAQAPTKQPPRSSPNT VKRPTKKGRDRAGKGQKPRGKEQLA KRKTFSLVKEKKAARTLSAILLAFI LTWTPYNIMVLVSTFCKDCVPETLW ELGYWLCYVNSTINPMCYALCNKAF RDTFRLLLLCRWDKRRWRKIPKRPG SVHRTPSRQC
• Applications: Antibody Production
  Functional Study
  Compound Screening
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: CHRM1 cholinergic receptor, muscarinic 1 [ Homo sapiens ]
• Official Symbol: CHRM1
• Synonyms: CHRM1; cholinergic receptor, muscarinic 1; muscarinic acetylcholine receptor M1; acetylcholine receptor; muscarinic 1; acetylcholine receptor, muscarinic 1; M1; HM1; M1R; MGC30125
• Gene ID: 1128
• mRNA Refseq: NM_000738
• Protein Refseq: NP_000729
• MIM: 118510
• UniProt ID: P11229