Recombinant Full Length Human CLN3 Protein, C-Flag-tagged

• Cat.No.: CLN3-1022HFL
• Product Overview: Recombinant Full Length Human CLN3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.4 kDa
• AA Sequence: MGGCAGSRRRFSDSEGEETVPEPRL PLLDHQGAHWKNAVGFWLLGLCNNF SYVVMLSAAHDILSHKRTSG NQSHVDPGPTPIPHNSSSRFDCNSV STAAVLLADILPTLVIKLLAPLGLH LLPYSPRVLVSGICAAGSFV LVAFSHSVGTSLCGVVFASISSGLG EVTFLSLTAFYPRAVISWWSSGTGG AGLLGALSYLGLTQAGLSPQ QTLLSMLGIPALLLASYFLLLTSPE AQDPGGEEEAESAARQPLIRTEAPE SKPGSSSSLSLRERWTVFKG LLWYIVPLVVVYFAEYFINQGLFEL LFFWNTSLSHAQQYRWYQMLYQAGV FASRSSLRCCRIRFTWALAL LQCLNLVFLLADVWFGFLPSIYLVF LIILYEGLLGGAAYVNTFHNIALET SDEHREFAMAATCISDTLGI
  SLSGLLALPLHDFLCQLSTRTRPLE QKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Lysosome

Gene Information

• Gene Name: CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin [ Homo sapiens (human) ]
• Official Symbol: CLN3
• Synonyms: BTS; BTN1; JNCL
• Gene ID: 1201
• mRNA Refseq: NM_001042432.2
• Protein Refseq: NP_001035897.1
• MIM: 607042
• UniProt ID: Q13286